PF3D7_0507500 | subtilisin-like protease 1

UniProt_ID: Q8I0V0

Computed_GO_Component_IDs:
Computed_GO_Components:
Computed_GO_Function_IDs: GO:0004252
Computed_GO_Functions: serine-type endopeptidase activity
Computed_GO_Process_IDs: GO:0006508
Computed_GO_Processes: proteolysis
Curated_GO_Component_IDs: GO:0044311 GO:0020026 GO:0020003
Curated_GO_Components: exoneme merozoite dense granule symbiont-containing vacuole
Curated_GO_Function_IDs: GO:0004252 GO:0008236
Curated_GO_Functions: serine-type endopeptidase activity serine-type peptidase activity
Curated_GO_Processes: exit from host cell proteolysis

	_ID	Prediction	OTHER	SP	mTP	CS_Position
	PF3D7_0507500	SP	0.385818	0.613777	0.000406	CS pos: 25-26. CLG-KE. Pr: 0.7104

No Results

Fasta :-
>PF3D7_0507500 MMLNKKVVALCTLTLHLFCIFLCLGKEVRSEENGKIQDDAKKIVSELRFLEKVEDVIEKS NIGGNEVDADENSFNPDTEVPIEEIEEIKMRELKDVKEEKNKNDNHNNNNNNISSSSSSS SNTFGEEKEEVSKKKKKLRLIVSENHATTPSFFQESLLEPDVLSFLESKGNLSNLKNINS MIIELKEDTTDDELISYIKILEEKGALIESDKLVSADNIDISGIKDAIRRGEENIDVNDY KSMLEVENDAEDYDKMFGMFNESHAATSKRKRHSTNERGYDTFSSPSYKTYSKSDYLYDD DNNNNNYYYSHSSNGHNSSSRNSSSSRSRPGKYHFNDEFRNLQWGLDLSRLDETQELINE HQVMSTRICVIDSGIDYNHPDLKDNIELNLKELHGRKGFDDDNNGIVDDIYGANFVNNSG NPMDDNYHGTHVSGIISAIGNNNIGVVGVDVNSKLIICKALDEHKLGRLGDMFKCLDYCI SRNAHMINGSFSFDEYSGIFNSSVEYLQRKGILFFVSASNCSHPKSSTPDIRKCDLSINA KYPPILSTVYDNVISVANLKKNDNNNHYSLSINSFYSNKYCQLAAPGTNIYSTAPHNSYR KLNGTSMAAPHVAAIASLIFSINPDLSYKKVIQILKDSIVYLPSLKNMVAWAGYADINKA VNLAIKSKKTYINSNISNKWKKKSRYLH
Download Fasta

MitoProt II - v1.101 File : /home/rajan/sadaf/4480_mitoprot/test/PF3D7_0507500.fa Sequence name : PF3D7_0507500 Sequence length : 688 VALUES OF COMPUTED PARAMETERS Coef20 : 4.628 CoefTot : 0.033 ChDiff : -17 ZoneTo : 26 KR : 3 DE : 0 CleavSite : 0 HYDROPHOBIC SCALE USED GES KD GVH1 ECS H17 : 2.171 2.482 0.571 0.735 MesoH : -0.305 0.413 -0.356 0.246 MuHd_075 : 21.374 14.801 7.065 5.433 MuHd_095 : 17.845 15.628 7.809 4.399 MuHd_100 : 21.222 14.640 7.907 4.921 MuHd_105 : 20.681 14.179 6.821 4.536 Hmax_075 : 19.162 21.900 6.612 6.650 Hmax_095 : 17.412 19.862 5.728 7.088 Hmax_100 : 18.800 23.800 6.727 7.620 Hmax_105 : 19.000 22.200 4.803 6.950 CLASS NOT-MITO MITO(/CHLORO) DFM : 0.9411 0.0589 DFMC : 0.9295 0.0705

##### ProP v.1.0b ProPeptide Cleavage Site Prediction ##### ##### Furin-type cleavage site prediction (Arginine/Lysine residues) ##### 688 PF3D7_0507500 MMLNKKVVALCTLTLHLFCIFLCLGKEVRSEENGKIQDDAKKIVSELRFLEKVEDVIEKSNIGGNEVDADENSFNPDTEV 80 PIEEIEEIKMRELKDVKEEKNKNDNHNNNNNNISSSSSSSSNTFGEEKEEVSKKKKKLRLIVSENHATTPSFFQESLLEP 160 DVLSFLESKGNLSNLKNINSMIIELKEDTTDDELISYIKILEEKGALIESDKLVSADNIDISGIKDAIRRGEENIDVNDY 240 KSMLEVENDAEDYDKMFGMFNESHAATSKRKRHSTNERGYDTFSSPSYKTYSKSDYLYDDDNNNNNYYYSHSSNGHNSSS 320 RNSSSSRSRPGKYHFNDEFRNLQWGLDLSRLDETQELINEHQVMSTRICVIDSGIDYNHPDLKDNIELNLKELHGRKGFD 400 DDNNGIVDDIYGANFVNNSGNPMDDNYHGTHVSGIISAIGNNNIGVVGVDVNSKLIICKALDEHKLGRLGDMFKCLDYCI 480 SRNAHMINGSFSFDEYSGIFNSSVEYLQRKGILFFVSASNCSHPKSSTPDIRKCDLSINAKYPPILSTVYDNVISVANLK 560 KNDNNNHYSLSINSFYSNKYCQLAAPGTNIYSTAPHNSYRKLNGTSMAAPHVAAIASLIFSINPDLSYKKVIQILKDSIV 640 YLPSLKNMVAWAGYADINKAVNLAIKSKKTYINSNISNKWKKKSRYLH 720 ................................................................................ 80 ................................................................................ 160 ................................................................................ 240 ................................................................................ 320 ................................................................................ 400 ................................................................................ 480 ................................................................................ 560 ................................................................................ 640 ................................................ 720 Propeptide cleavage sites predicted: Arg(R)/Lys(K): 0 Name Pos Context Score Pred ____________________________v_________________ PF3D7_0507500 5 --MMLNK|KV 0.066 . PF3D7_0507500 6 -MMLNKK|VV 0.092 . PF3D7_0507500 26 IFLCLGK|EV 0.069 . PF3D7_0507500 29 CLGKEVR|SE 0.148 . PF3D7_0507500 35 RSEENGK|IQ 0.074 . PF3D7_0507500 41 KIQDDAK|KI 0.071 . PF3D7_0507500 42 IQDDAKK|IV 0.139 . PF3D7_0507500 48 KIVSELR|FL 0.156 . PF3D7_0507500 52 ELRFLEK|VE 0.069 . PF3D7_0507500 59 VEDVIEK|SN 0.080 . PF3D7_0507500 89 EEIEEIK|MR 0.057 . PF3D7_0507500 91 IEEIKMR|EL 0.112 . PF3D7_0507500 94 IKMRELK|DV 0.277 . PF3D7_0507500 97 RELKDVK|EE 0.053 . PF3D7_0507500 100 KDVKEEK|NK 0.067 . PF3D7_0507500 102 VKEEKNK|ND 0.062 . PF3D7_0507500 128 NTFGEEK|EE 0.053 . PF3D7_0507500 133 EKEEVSK|KK 0.057 . PF3D7_0507500 134 KEEVSKK|KK 0.088 . PF3D7_0507500 135 EEVSKKK|KK 0.103 . PF3D7_0507500 136 EVSKKKK|KL 0.118 . PF3D7_0507500 137 VSKKKKK|LR 0.091 . PF3D7_0507500 139 KKKKKLR|LI 0.120 . PF3D7_0507500 169 LSFLESK|GN 0.063 . PF3D7_0507500 176 GNLSNLK|NI 0.060 . PF3D7_0507500 186 SMIIELK|ED 0.059 . PF3D7_0507500 199 ELISYIK|IL 0.062 . PF3D7_0507500 204 IKILEEK|GA 0.065 . PF3D7_0507500 212 ALIESDK|LV 0.075 . PF3D7_0507500 225 IDISGIK|DA 0.068 . PF3D7_0507500 229 GIKDAIR|RG 0.082 . PF3D7_0507500 230 IKDAIRR|GE 0.130 . PF3D7_0507500 241 IDVNDYK|SM 0.094 . PF3D7_0507500 255 DAEDYDK|MF 0.071 . PF3D7_0507500 269 SHAATSK|RK 0.065 . PF3D7_0507500 270 HAATSKR|KR 0.184 . PF3D7_0507500 271 AATSKRK|RH 0.099 . PF3D7_0507500 272 ATSKRKR|HS 0.314 . PF3D7_0507500 278 RHSTNER|GY 0.112 . PF3D7_0507500 289 FSSPSYK|TY 0.083 . PF3D7_0507500 293 SYKTYSK|SD 0.066 . PF3D7_0507500 321 GHNSSSR|NS 0.111 . PF3D7_0507500 327 RNSSSSR|SR 0.159 . PF3D7_0507500 329 SSSSRSR|PG 0.110 . PF3D7_0507500 332 SRSRPGK|YH 0.269 . PF3D7_0507500 340 HFNDEFR|NL 0.118 . PF3D7_0507500 350 WGLDLSR|LD 0.077 . PF3D7_0507500 367 HQVMSTR|IC 0.073 . PF3D7_0507500 383 YNHPDLK|DN 0.067 . PF3D7_0507500 391 NIELNLK|EL 0.053 . PF3D7_0507500 396 LKELHGR|KG 0.090 . PF3D7_0507500 397 KELHGRK|GF 0.085 . PF3D7_0507500 454 GVDVNSK|LI 0.059 . PF3D7_0507500 459 SKLIICK|AL 0.068 . PF3D7_0507500 465 KALDEHK|LG 0.056 . PF3D7_0507500 468 DEHKLGR|LG 0.079 . PF3D7_0507500 474 RLGDMFK|CL 0.069 . PF3D7_0507500 482 LDYCISR|NA 0.102 . PF3D7_0507500 509 SVEYLQR|KG 0.073 . PF3D7_0507500 510 VEYLQRK|GI 0.080 . PF3D7_0507500 525 SNCSHPK|SS 0.091 . PF3D7_0507500 532 SSTPDIR|KC 0.101 . PF3D7_0507500 533 STPDIRK|CD 0.065 . PF3D7_0507500 541 DLSINAK|YP 0.063 . PF3D7_0507500 560 ISVANLK|KN 0.061 . PF3D7_0507500 561 SVANLKK|ND 0.091 . PF3D7_0507500 579 NSFYSNK|YC 0.067 . PF3D7_0507500 600 APHNSYR|KL 0.116 . PF3D7_0507500 601 PHNSYRK|LN 0.094 . PF3D7_0507500 629 NPDLSYK|KV 0.090 . PF3D7_0507500 630 PDLSYKK|VI 0.078 . PF3D7_0507500 636 KVIQILK|DS 0.071 . PF3D7_0507500 646 VYLPSLK|NM 0.051 . PF3D7_0507500 659 GYADINK|AV 0.077 . PF3D7_0507500 666 AVNLAIK|SK 0.082 . PF3D7_0507500 668 NLAIKSK|KT 0.069 . PF3D7_0507500 669 LAIKSKK|TY 0.105 . PF3D7_0507500 679 NSNISNK|WK 0.073 . PF3D7_0507500 681 NISNKWK|KK 0.095 . PF3D7_0507500 682 ISNKWKK|KS 0.112 . PF3D7_0507500 683 SNKWKKK|SR 0.158 . PF3D7_0507500 685 KWKKKSR|YL 0.150 . ____________________________^_________________

Fasta :-
>PF3D7_0507500 ATGATGCTCAATAAAAAAGTTGTTGCTTTGTGCACACTTACCTTACATCTTTTTTGTATA TTTCTATGTCTAGGAAAGGAAGTAAGGTCTGAAGAAAATGGGAAAATACAAGATGATGCT AAAAAGATTGTTAGCGAATTACGATTCCTAGAAAAAGTAGAAGATGTTATTGAAAAGAGT AACATAGGAGGGAATGAGGTAGATGCCGATGAAAATTCATTTAATCCGGATACTGAGGTT CCCATAGAAGAGATAGAAGAAATAAAAATGAGGGAACTGAAAGATGTAAAGGAAGAAAAA AATAAAAATGACAACCATAATAATAATAATAATAATATTAGTAGTAGTAGTAGTAGTAGT AGTAATACTTTTGGTGAAGAAAAAGAAGAAGTATCTAAGAAAAAAAAAAAGTTAAGACTT ATAGTTAGCGAGAATCATGCAACTACCCCCTCGTTTTTCCAAGAATCCCTTTTAGAACCT GATGTTTTATCCTTTTTAGAAAGTAAAGGGAATTTGTCCAACTTGAAAAATATCAATTCT ATGATTATAGAACTAAAGGAAGATACAACGGATGATGAATTAATATCTTATATTAAAATT CTTGAGGAGAAGGGAGCTTTGATTGAATCAGATAAATTAGTGAGTGCAGATAATATTGAT ATAAGTGGTATAAAAGATGCTATAAGAAGAGGTGAAGAAAATATTGATGTTAATGATTAT AAAAGTATGTTAGAAGTCGAAAATGATGCTGAAGATTATGATAAAATGTTTGGTATGTTT AATGAATCACATGCTGCAACATCTAAAAGGAAACGCCATTCAACAAATGAGCGTGGATAT GATACATTTTCATCACCTTCATATAAGACATATTCAAAAAGTGATTATTTATATGATGAT GATAATAATAATAATAATTATTATTATAGTCATAGTAGTAATGGTCATAATAGTAGTAGT CGTAATAGTAGTAGTAGTCGTAGTAGACCAGGTAAATATCATTTCAATGATGAATTTCGT AATTTGCAATGGGGTTTAGATTTATCCAGATTAGATGAAACACAAGAATTAATTAACGAA CATCAAGTGATGAGTACTCGTATATGTGTTATAGATAGTGGTATTGATTATAATCATCCC GATTTAAAAGATAATATTGAATTAAATTTAAAAGAATTACATGGAAGGAAAGGTTTTGAT GATGATAATAATGGTATAGTTGATGATATATATGGTGCTAATTTTGTAAATAATTCAGGA AACCCGATGGATGATAATTATCATGGTACTCATGTATCAGGAATTATATCTGCCATAGGA AATAATAATATAGGTGTTGTAGGTGTTGATGTAAATTCAAAATTAATTATTTGTAAAGCA TTAGATGAACATAAATTAGGAAGATTAGGAGATATGTTCAAATGTTTAGATTATTGTATA AGTAGAAATGCACATATGATAAATGGAAGCTTTTCATTTGATGAATATAGTGGTATTTTT AATTCTTCTGTAGAATATTTACAAAGAAAAGGTATCCTCTTTTTTGTATCTGCAAGTAAT TGTAGTCATCCTAAATCGTCAACACCAGATATTAGAAAATGTGATTTATCCATAAATGCA AAATATCCCCCTATCTTATCTACTGTTTATGATAATGTTATATCTGTTGCTAATTTAAAA AAAAATGATAATAATAATCATTATTCATTATCCATTAATTCTTTTTATAGCAATAAATAT TGTCAACTAGCTGCACCAGGAACTAATATATATTCTACTGCTCCACATAATTCATATCGA AAATTAAATGGTACATCTATGGCTGCTCCACATGTAGCTGCAATAGCATCACTCATATTT TCTATTAATCCTGACTTATCATATAAAAAAGTTATACAAATATTAAAAGATTCTATTGTA TATCTCCCTTCCTTAAAAAATATGGTTGCATGGGCAGGATATGCAGATATAAATAAGGCA GTCAATTTAGCCATAAAATCAAAAAAAACATATATCAATTCTAATATATCTAACAAGTGG AAAAAAAAAAGTAGATATTTGCATTAA
Download Fasta

Fasta :-

MMLNKKVVALCTLTLHLFCIFLCLGKEVRSEENGKIQDDAKKIVSELRFLEKVEDVIEKS NIGGNEVDADENSFNPDTEVPIEEIEEIKMRELKDVKEEKNKNDNHNNNNNNISSSSSSS SNTFGEEKEEVSKKKKKLRLIVSENHATTPSFFQESLLEPDVLSFLESKGNLSNLKNINS MIIELKEDTTDDELISYIKILEEKGALIESDKLVSADNIDISGIKDAIRRGEENIDVNDY KSMLEVENDAEDYDKMFGMFNESHAATSKRKRHSTNERGYDTFSSPSYKTYSKSDYLYDD DNNNNNYYYSHSSNGHNSSSRNSSSSRSRPGKYHFNDEFRNLQWGLDLSRLDETQELINE HQVMSTRICVIDSGIDYNHPDLKDNIELNLKELHGRKGFDDDNNGIVDDIYGANFVNNSG NPMDDNYHGTHVSGIISAIGNNNIGVVGVDVNSKLIICKALDEHKLGRLGDMFKCLDYCI SRNAHMINGSFSFDEYSGIFNSSVEYLQRKGILFFVSASNCSHPKSSTPDIRKCDLSINA KYPPILSTVYDNVISVANLKKNDNNNHYSLSINSFYSNKYCQLAAPGTNIYSTAPHNSYR KLNGTSMAAPHVAAIASLIFSINPDLSYKKVIQILKDSIVYLPSLKNMVAWAGYADINKA VNLAIKSKKTYINSNISNKWKKKSRYLH

Subtilases

title: catalytic triad
coordinates: D372,H428,S606

PF3D7_0507500.pdb

PF3D7_0507500_site1.pdb

PF3D7_0507500_site2.pdb

PF3D7_0507500_site3.pdb

PF3D7_0507500_site4.pdb

PF3D7_0507500_site5.pdb

No Results

	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method
	PF3D7_0507500	132 S	KEEVSKKKK	0.99	unsp	PF3D7_0507500	132 S	KEEVSKKKK	0.99	unsp	PF3D7_0507500	132 S	KEEVSKKKK	0.99	unsp	PF3D7_0507500	274 S	RKRHSTNER	0.997	unsp	PF3D7_0507500	292 S	YKTYSKSDY	0.993	unsp	PF3D7_0507500	323 S	SSRNSSSSR	0.993	unsp	PF3D7_0507500	324 S	SRNSSSSRS	0.997	unsp	PF3D7_0507500	326 S	NSSSSRSRP	0.995	unsp	PF3D7_0507500	527 S	HPKSSTPDI	0.995	unsp	PF3D7_0507500	30 S	KEVRSEENG	0.996	unsp	PF3D7_0507500	119 S	SSSSSSSNT	0.995	unsp

PF3D7_0507500 | subtilisin-like protease 1

ID's

UniProt_ID: Q8I0V0

GEO Functions

Computed_GO_Component_IDs:

Computed_GO_Components:

Computed_GO_Function_IDs: GO:0004252

Computed_GO_Functions: serine-type endopeptidase activity

Computed_GO_Process_IDs: GO:0006508

Computed_GO_Processes: proteolysis

Curated_GO_Component_IDs: GO:0044311 GO:0020026 GO:0020003

Curated_GO_Components: exoneme merozoite dense granule symbiont-containing vacuole

Curated_GO_Function_IDs: GO:0004252 GO:0008236

Curated_GO_Functions: serine-type endopeptidase activity serine-type peptidase activity

Curated_GO_Processes: exit from host cell proteolysis

Subcellular Localization

Targetp

Signalp

Fasta :-

Mitoprot

ProPeptide Prediction

Sequence

Nucleotide sequence

Fasta :-

Protein sequence

Fasta :-

Domains

Subtilases

Structure

Post Translational Modifications

N_Linked Glycosylation

O_Linked Glycosylation

Phosphorylation

Protein-Protein Interaction

String

MAL5P1.76 PFE0370c

Literature

PubMed

Google Scholar

Dinesh Gupta lab Translational bioinformatics group, ICGEB, New Delhi, India