SPAC24C9.14 | ubiquitin-specific cysteine protease, OTU family, Otu1

UniProt_ID: O13974

Computed_GO_Component_IDs:
Computed_GO_Components:
Computed_GO_Function_IDs: GO:0046872 GO:0004843 GO:1904265
Computed_GO_Functions: metal ion binding thiol-dependent ubiquitin-specific protease activity ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol
Computed_GO_Process_IDs: GO:0016579
Computed_GO_Processes: protein deubiquitination
Curated_GO_Component_IDs: GO:0005737 GO:0005829 GO:0005634
Curated_GO_Components: cytoplasm cytosol nucleus
Curated_GO_Function_IDs: GO:0004843
Curated_GO_Functions: thiol-dependent ubiquitin-specific protease activity
Curated_GO_Processes: endoplasmic reticulum unfolded protein response protein deubiquitination ubiquitin-dependent ERAD pathway

	_ID	Prediction	OTHER	SP	mTP	CS_Position
	SPAC24C9.14	OTHER	0.998744	0.000021	0.001235

No Results

Fasta :-
>SPAC24C9.14 MSSLRLRLKYENQSAVETVEANATVGSFLDLVAAKFSLPRNSIALKFGFPPQDIPLVNSD VPLSTLVSSGQQILVLKNAATSFSTNEPAKPPIPNAATKPTFPPQTEISNPPAVSHQSKN TSQDPPYVSTPIGDIALRVMPDDNSCLFRALSKPLGFSPYELREIVANQVLSNPDIYSTA ILGKPSIEYASWIRKETSWGGYIELSILSSHFGVEICSVDVKTGRVDSYNPQPATGQRTY IVYSGIHYDLAALAAVLWDTDVDVVLFDASDVTITPYVQQLASLLKNMHYYTDTASFSIR CTICGTGLVGEKDATAHALATGHTQFGEY
Download Fasta

MitoProt II - v1.101 File : /home/rajan/sadaf/4480_mitoprot/test/130 Sequence name : 130 Sequence length : 329 VALUES OF COMPUTED PARAMETERS Coef20 : 4.201 CoefTot : 0.590 ChDiff : -8 ZoneTo : 10 KR : 3 DE : 0 CleavSite : 0 HYDROPHOBIC SCALE USED GES KD GVH1 ECS H17 : 0.965 1.594 0.284 0.606 MesoH : -0.158 0.533 -0.222 0.288 MuHd_075 : 9.386 7.769 3.172 2.013 MuHd_095 : 11.775 12.283 4.502 2.901 MuHd_100 : 9.639 10.818 3.164 2.341 MuHd_105 : 4.904 6.083 1.125 0.982 Hmax_075 : -4.900 1.050 -2.599 -0.070 Hmax_095 : 0.200 8.500 -2.060 3.040 Hmax_100 : -1.200 7.500 -2.367 1.890 Hmax_105 : -7.000 1.575 -3.276 0.805 CLASS NOT-MITO MITO(/CHLORO) DFM : 0.9499 0.0501 DFMC : 0.9581 0.0419

##### ProP v.1.0b ProPeptide Cleavage Site Prediction ##### ##### Furin-type cleavage site prediction (Arginine/Lysine residues) ##### 329 SPAC24C9.14 MSSLRLRLKYENQSAVETVEANATVGSFLDLVAAKFSLPRNSIALKFGFPPQDIPLVNSDVPLSTLVSSGQQILVLKNAA 80 TSFSTNEPAKPPIPNAATKPTFPPQTEISNPPAVSHQSKNTSQDPPYVSTPIGDIALRVMPDDNSCLFRALSKPLGFSPY 160 ELREIVANQVLSNPDIYSTAILGKPSIEYASWIRKETSWGGYIELSILSSHFGVEICSVDVKTGRVDSYNPQPATGQRTY 240 IVYSGIHYDLAALAAVLWDTDVDVVLFDASDVTITPYVQQLASLLKNMHYYTDTASFSIRCTICGTGLVGEKDATAHALA 320 TGHTQFGEY 400 ................................................................................ 80 ................................................................................ 160 ................................................................................ 240 ................................................................................ 320 ......... 400 Propeptide cleavage sites predicted: Arg(R)/Lys(K): 0 Name Pos Context Score Pred ____________________________v_________________ SPAC24C9.14 5 --MSSLR|LR 0.083 . SPAC24C9.14 7 MSSLRLR|LK 0.102 . SPAC24C9.14 9 SLRLRLK|YE 0.068 . SPAC24C9.14 35 LDLVAAK|FS 0.063 . SPAC24C9.14 40 AKFSLPR|NS 0.084 . SPAC24C9.14 46 RNSIALK|FG 0.077 . SPAC24C9.14 77 QQILVLK|NA 0.070 . SPAC24C9.14 90 STNEPAK|PP 0.073 . SPAC24C9.14 99 IPNAATK|PT 0.087 . SPAC24C9.14 119 AVSHQSK|NT 0.104 . SPAC24C9.14 138 IGDIALR|VM 0.066 . SPAC24C9.14 149 DNSCLFR|AL 0.164 . SPAC24C9.14 153 LFRALSK|PL 0.069 . SPAC24C9.14 163 FSPYELR|EI 0.082 . SPAC24C9.14 184 STAILGK|PS 0.068 . SPAC24C9.14 194 EYASWIR|KE 0.070 . SPAC24C9.14 195 YASWIRK|ET 0.135 . SPAC24C9.14 222 ICSVDVK|TG 0.059 . SPAC24C9.14 225 VDVKTGR|VD 0.079 . SPAC24C9.14 238 QPATGQR|TY 0.085 . SPAC24C9.14 286 QLASLLK|NM 0.062 . SPAC24C9.14 300 TASFSIR|CT 0.162 . SPAC24C9.14 312 TGLVGEK|DA 0.072 . ____________________________^_________________

Fasta :-
>SPAC24C9.14 GCTTTACATTCAAGACGTTTGTTGGTATATTCTTTTGCTGATTCATTATAATTTTCTTTC AAATTTAGAAATAAAGTTATTGTACCTAAGTTAAAAATTCCAGAGTTTTCTAGAAAAAAG AAGAAAACAAGAAACTGGTTACTCAATTTCCCTTATTAGGGAAAATCGGTTGTTTAGTGA AGCTTTTGTTTGGTGTGCTATTGTCAGTTTCATTTACATAGTAGGATTTGGTAATTTTTT GAGAACGCTCTCTTTAAGTGTACTCCTGTTTCTCCCGTTTACGGCTGATTGCTTTTTTGC AACGTTCCGGGTTTGTTAAAATTATCTGACTATGTCTTCACTACGTCTTCGTTTAAAATA CGAAAATCAGTCTGCTGTAGAGACAGTTGAAGCAAATGCGACTGTTGGATCCTTTTTAGA CTTAGTGGCAGCGAAATTCTCGTTGCCTAGAAACTCGATTGCTTTAAAATTCGGATTTCC TCCTCAAGATATTCCTTTAGTTAATTCAGACGTTCCTTTATCGACGTTGGTTTCTTCAGG ACAGCAAATCCTCGTTCTCAAAAATGCCGCTACCTCATTTTCAACGAATGAACCAGCAAA ACCTCCAATTCCTAATGCAGCCACAAAACCTACATTCCCACCGCAAACAGAGATCTCCAA TCCCCCAGCTGTGTCGCACCAGTCCAAAAACACAAGTCAAGATCCTCCGTACGTCAGTAC CCCAATTGGTGATATTGCGCTCCGCGTGATGCCAGACGATAACTCTTGTTTGTTTCGTGC ATTGTCAAAGCCTCTTGGATTCTCTCCGTACGAGCTTCGTGAAATTGTAGCTAATCAAGT TCTCTCTAATCCTGACATTTACTCTACTGCCATTTTAGGGAAGCCGTCCATCGAGTATGC TTCATGGATTCGGAAGGAAACTAGCTGGGGTGGATACATCGAGCTATCAATTTTGTCTAG CCACTTTGGAGTTGAAATTTGTTCCGTTGACGTCAAAACTGGTCGGGTGGATTCCTATAA TCCACAACCGGCCACAGGGCAACGTACTTATATTGTCTACTCTGGAATTCATTATGATTT GGCTGCCTTAGCCGCTGTTCTTTGGGATACTGATGTCGACGTAGTATTATTTGATGCTTC TGATGTTACAATAACCCCATATGTTCAACAACTTGCATCTCTATTAAAGAATATGCATTA CTACACTGACACTGCATCCTTTTCTATTCGATGTACCATTTGTGGAACTGGTTTAGTTGG AGAAAAAGATGCAACCGCACATGCTCTTGCAACGGGTCATACACAGTTTGGTGAGTATTA ATGTCTATTTTAATGATCTTTAAAAAATATGTTTGGTTATGATTTAGCCCATTATTTTCT ACAGAGTTTGCTTTGTGAAGATTTTCTCTCAAAGTGAAGTTCTAGTGATGAATTAATCTA TTGCGAAAACAGTGTTTTTCTGGGTTGCTTCAATCGATTATTTTCGATATTGGTGTGCAT GTCCTCCTTGACGAAATATTTCTTCATGATGTTGCTTTAGAAAAAATCCAAGTGATATTT AACAAACTATAAAACTTGTTAACAATTAGACAGCAAGATGTATTAGTTGTTAAAAATAGT TTATGCTAAGATGCCTGCTTTTTTCACTTTTTCAGGCCCGATTTCCTTAATGAGACGATT TTTCTCTTCTTCTAGCGCGGTAATACGCTTCTTTAATGCATGCTTGTAGTCTTTATGATG AGTTTTAAGATTTGTTTCTAACAACTCTAAGTTATTCTCCTTCTCCCTATACTTTTCCTT CATCACCTTTGTTAGAGCTTCTTCTACTAACTGTGTTTGTTCGCTAATGTACTTCTGATT CATCTCTTCGGCACTATATCTTTAGTTAGCAAGTTTGATGATTCACATGTAATGTATCAA CGTACCTGATGAATTGACTCCCTGGTGTGGCATTTAAAGCAACTAGTTTTTCTGTACGGA AAGTATCGTAGATTAGCTTATGTGTCTTGTGTTTAAGCCCTTCAATATGCGTGTAAAGCA AAAAGTTACGTAGTTGGCAAAAGTCCGACTGCTTGGGATCATCGATATCGACTAAACCCC AGGGATAAGCTCTACCTCGAATGCATTTGCCATCATGTTCAATGGGTGCCCCGGCACCCA CTATAGCAAAAGGTATAGGGATCTTTGCCTTTTTTTCATTATGGGGTTCTCTAAAATAAC GAATTTTTTCTCGAACCATATCGGCGATAACACGCTTTTTGAAATGATTCAATTCATCGG AAGTCATAGTGTCTGCCTTGCCAATCACCGGAATAATGTTGACAAACTGATCGATTTTTT TCATGATGTAAATTTCGAGTGGCTGAAGTCTATGGCCATTTGGATTTATAAAAAACAGAC ATCCATGAATCCTAGAATCGATTTCAGATGTTTCCCTATCCATTTTTACCTCATTTTGAA AATACGCGTTTAGCCTGTGTAGCAAATTGGTAGCAATGGGTCTCCAGCTAGAAGGTTAGT TTGAATTGGGTTATGTCAAAAAAAAAAACGAAAAAAGAATAGAAGATATTCTAATAGCTT ACCAATTGCTATTGTCACTTTTATCGCCAAAACCAGGTGTATCGACGATTGTGAGGTTGA ATTTCTGATCGCCGTCTGAAAGTGTCGCCTTATGTTCCACAAAGTCCATCGTTTTTTTAG GTCTGAAGTTTGTATCGTTGCTTTGGAGAAAAGAATTGACAAAAGTGGTTTTTCCCAAAC TACTTTCTCCGACGACTATTAAATTGATATCGATTCCATTTCTACAGACCCGACTGTAGT GCTGATGGTTAAAATCATTAATCCCAATATTATTGCAGGGATGAAAGGTAGGTATTGATT TACCGTTTGAGTTTGGAACCTCATCTTGTTTAAACTCAGTCTTCTTATCCTTGGCGGTAT CAGATTGAGGGCATTGATCGTCTCCTTGTTGATCGCTTGCAATTTGCTCTTTCCTTGTAA CATCTTTACTTTTTCTGCTTTCGTTACTAACGCTTCGTTTTGCAGAGCTCTCATCTACTT GTTTTATTGTTATAATCGCCTCTTCTGTCAGTTTAAGCTGGCCCTCCTGCGGCATTGATG AAGACAAATTTGAGCTATCCATGGTTTCAGCCTAAAGCAATACAGAATTTTTTATTCTGA TTTATACTTAAAACGAATAGTAATACAATGGGTTTCTACTACTTTGCTCAAATATTGCTG CTTGAAATATTGGTTGGGTGGAATTGGTAAAACACAAGGTTCTTAAAATTAAGCATTTGT TTGTTGTGTTTACTTTCAAAGGCAACGTTGCGGTAAAGATATAATCCACTCAAAGGCACA TTGACAAGAAGTAAACAATCGATGCCTAACGTCATGCGAGTCATGTAAACAAACAAACAT TTGATCCTTTTAATTACATGCATAAAAGATTTTATTCTGATTTAAAGGATAGCGCGTGTA TGTTTGATTTTGTTTAGTCTTCTGTTCACAATATACTTGATAAGAACATGTGTGAAGGAA AACAAAAACTGTGTACGATAATTGTGACCGCATGGAGAATGAAAATGAATTGATGCAATG AACAAAGTGGAATTTTCATTAAATTATAAAAGAGAAATATTATAGTGTTAGTAAGCTAAA CAAAAAAGCGAGTGAGACGATACAGTACCAAATCCATCAAAAGGCTCCATGTCAAAATGC ATCTTTTTTTGAAAGCGTCCATAAGAAATAAATTGAATTGAAACTATATTATTATTTAAA TTCATGCTACTTGTTTTGATCTTCTTCAATCACCCTGTGTTTTGAACCATACTCCTCGTA TATCTATCTCATCCATCTTCCTATGGATTCCTTTCTACCCATCTCCAGAAAATAATACTT CATTTAACGCATTTTGTTTCTCACTCTATATATGCCTAGTAACACACCCCACCGCCTTAT GGTATCGTTTTTTAGCAAATTGTACCAATGCAATTTTAACTATATTCCTTAGCGAGTATG GTGCGTTTATGACATCATTGATAACTGAGCTGGCTTTGCTACGTGACGTTGCTTTTACAT CACTTTTCTGTCCCCTGTTTCATCACTACCACCATTCAATACGCTCATGTAAACACAACC GGTAAACGAGTATGGAGTAGCTTAGTGAAGTGGCGGGAGGAACCGATAAACGAATTTACT GTTCGCTAAGATTACGCCGTAATAAAAAAAGGAACCGGCAAAGATCGAGCCTGACTAGGC AACGCTTGCATTTTGCGCGCAGGCAATGGCGTTTACCAGGAGTAGTGGCTTTTATCCGTT TTCGTATACATTAACAACTTTCCAAATACCACAACCACGTTAGAAAGAATTGGTTTC
Download Fasta

Fasta :-

MSSLRLRLKYENQSAVETVEANATVGSFLDLVAAKFSLPRNSIALKFGFPPQDIPLVNSD VPLSTLVSSGQQILVLKNAATSFSTNEPAKPPIPNAATKPTFPPQTEISNPPAVSHQSKN TSQDPPYVSTPIGDIALRVMPDDNSCLFRALSKPLGFSPYELREIVANQVLSNPDIYSTA ILGKPSIEYASWIRKETSWGGYIELSILSSHFGVEICSVDVKTGRVDSYNPQPATGQRTY IVYSGIHYDLAALAAVLWDTDVDVVLFDASDVTITPYVQQLASLLKNMHYYTDTASFSIR CTICGTGLVGEKDATAHALATGHTQFGEY

Ubiquitin thiolesterase protein OTUB2 (Otubain-2)

title: VCP interaction site
coordinates: R7,A15,K46,F49,P51,D53,S68,S69,G70,Q71,Q72

	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore
	SPAC24C9.14	T	98	0.710	0.201	SPAC24C9.14	T	101	0.697	0.478	SPAC24C9.14	T	106	0.678	0.164	SPAC24C9.14	T	121	0.622	0.022	SPAC24C9.14	S	115	0.588	0.196	SPAC24C9.14	S	118	0.561	0.047	SPAC24C9.14	S	109	0.525	0.201	SPAC24C9.14	T	85	0.502	0.074

	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore
	SPAC24C9.14	T	98	0.710	0.201	SPAC24C9.14	T	101	0.697	0.478	SPAC24C9.14	T	106	0.678	0.164	SPAC24C9.14	T	121	0.622	0.022	SPAC24C9.14	S	115	0.588	0.196	SPAC24C9.14	S	118	0.561	0.047	SPAC24C9.14	S	109	0.525	0.201	SPAC24C9.14	T	85	0.502	0.074

	ID	Site	Peptide	Score	Method
	SPAC24C9.14	158 S	PLGFSPYEL	0.995	unsp

SPAC24C9.14 | ubiquitin-specific cysteine protease, OTU family, Otu1

ID's

UniProt_ID: O13974

GEO Functions

Computed_GO_Component_IDs:

Computed_GO_Components:

Computed_GO_Function_IDs: GO:0046872 GO:0004843 GO:1904265

Computed_GO_Functions: metal ion binding thiol-dependent ubiquitin-specific protease activity ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol

Computed_GO_Process_IDs: GO:0016579

Computed_GO_Processes: protein deubiquitination

Curated_GO_Component_IDs: GO:0005737 GO:0005829 GO:0005634

Curated_GO_Components: cytoplasm cytosol nucleus

Curated_GO_Function_IDs: GO:0004843

Curated_GO_Functions: thiol-dependent ubiquitin-specific protease activity

Curated_GO_Processes: endoplasmic reticulum unfolded protein response protein deubiquitination ubiquitin-dependent ERAD pathway

Subcellular Localization

Targetp

Signalp

Fasta :-

Mitoprot

ProPeptide Prediction

Sequence

Nucleotide sequence

Fasta :-

Protein sequence

Fasta :-

Domains

Ubiquitin thiolesterase protein OTUB2 (Otubain-2)

Structure

Post Translational Modifications

N_Linked Glycosylation

O_Linked Glycosylation

Phosphorylation

Protein-Protein Interaction

String

SPAC24C9.14

Literature

PubMed

Google Scholar

Dinesh Gupta lab Translational bioinformatics group, ICGEB, New Delhi, India