YLR120C | aspartyl protease

UniProt_ID: P32329

Computed_GO_Component_IDs: GO:0031225 GO:0016020 GO:0005886
Computed_GO_Components: anchored component of membrane membrane plasma membrane
Computed_GO_Function_IDs: GO:0004190 GO:0016787 GO:0008233
Computed_GO_Functions: aspartic-type endopeptidase activity hydrolase activity peptidase activity
Computed_GO_Process_IDs: GO:0006508
Computed_GO_Processes: proteolysis
Curated_GO_Component_IDs: GO:0031362 GO:0046658 GO:0005576 GO:0009277
Curated_GO_Components: anchored component of external side of plasma membrane anchored component of plasma membrane extracellular region fungal-type cell wall
Curated_GO_Function_IDs: GO:0004190
Curated_GO_Functions: aspartic-type endopeptidase activity
Curated_GO_Processes: fungal-type cell wall organization peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion protein catabolic process protein processing proteolysis signal transduction involved in filamentous growth

	_ID	Prediction	OTHER	SP	mTP	CS_Position
	YLR120C	SP	0.131772	0.844635	0.023593	CS pos: 21-22. VLG-KI. Pr: 0.8567

No Results

Fasta :-
>YLR120C MKLKTVRSAVLSSLFASQVLGKIIPAANKRDDDSNSKFVKLPFHKLYGDSLENVGSDKKP EVRLLKRADGYEEIIITNQQSFYSVDLEVGTPPQNVTVLVDTGSSDLWIMGSDNPYCSSN SMGSSRRRVIDKRDDSSSGGSLINDINPFGWLTGTGSAIGPTATGLGGGSGTATQSVPAS EATMDCQQYGTFSTSGSSTFRSNNTYFSISYGDGTFASGTFGTDVLDLSDLNVTGLSFAV ANETNSTMGVLGIGLPELEVTYSGSTASHSGKAYKYDNFPIVLKNSGAIKSNTYSLYLND SDAMHGTILFGAVDHSKYTGTLYTIPIVNTLSASGFSSPIQFDVTINGIGISDSGSSNKT LTTTKIPALLDSGTTLTYLPQTVVSMIATELGAQYSSRIGYYVLDCPSDDSMEIVFDFGG FHINAPLSSFILSTGTTCLLGIIPTSDDTGTILGDSFLTNAYVVYDLENLEISMAQARYN TTSENIEIITSSVPSAVKAPGYTNTWSTSASIVTGGNIFTVNSSQTASFSGNLTTSTASA TSTSSKRNVGDHIVPSLPLTLISLLFAFI
Download Fasta

MitoProt II - v1.101 File : /home/rajan/sadaf/4480_mitoprot/test/YLR120C.fa Sequence name : YLR120C Sequence length : 569 VALUES OF COMPUTED PARAMETERS Coef20 : 4.962 CoefTot : 0.526 ChDiff : -18 ZoneTo : 30 KR : 6 DE : 0 CleavSite : 0 HYDROPHOBIC SCALE USED GES KD GVH1 ECS H17 : 2.171 2.271 0.432 0.803 MesoH : 0.463 0.597 -0.100 0.355 MuHd_075 : 33.120 31.620 9.659 10.283 MuHd_095 : 27.718 22.074 9.016 6.412 MuHd_100 : 26.345 20.865 9.167 5.606 MuHd_105 : 25.214 20.050 9.141 5.397 Hmax_075 : 20.533 27.183 4.767 8.167 Hmax_095 : 18.500 19.775 4.247 7.440 Hmax_100 : 14.800 17.100 2.997 5.380 Hmax_105 : 14.600 17.100 3.026 5.460 CLASS NOT-MITO MITO(/CHLORO) DFM : 0.1353 0.8647 DFMC : 0.2157 0.7843 This protein is probably imported in mitochondria. f(Ser) = 0.1333 f(Arg) = 0.0667 CMi = 0.81633 CMi is the Chloroplast/Mitochondria Index It has been proposed by Von Heijne et al (Eur J Biochem,1989, 180: 535-545)

##### ProP v.1.0b ProPeptide Cleavage Site Prediction ##### ##### Furin-type cleavage site prediction (Arginine/Lysine residues) ##### 569 YLR120C MKLKTVRSAVLSSLFASQVLGKIIPAANKRDDDSNSKFVKLPFHKLYGDSLENVGSDKKPEVRLLKRADGYEEIIITNQQ 80 SFYSVDLEVGTPPQNVTVLVDTGSSDLWIMGSDNPYCSSNSMGSSRRRVIDKRDDSSSGGSLINDINPFGWLTGTGSAIG 160 PTATGLGGGSGTATQSVPASEATMDCQQYGTFSTSGSSTFRSNNTYFSISYGDGTFASGTFGTDVLDLSDLNVTGLSFAV 240 ANETNSTMGVLGIGLPELEVTYSGSTASHSGKAYKYDNFPIVLKNSGAIKSNTYSLYLNDSDAMHGTILFGAVDHSKYTG 320 TLYTIPIVNTLSASGFSSPIQFDVTINGIGISDSGSSNKTLTTTKIPALLDSGTTLTYLPQTVVSMIATELGAQYSSRIG 400 YYVLDCPSDDSMEIVFDFGGFHINAPLSSFILSTGTTCLLGIIPTSDDTGTILGDSFLTNAYVVYDLENLEISMAQARYN 480 TTSENIEIITSSVPSAVKAPGYTNTWSTSASIVTGGNIFTVNSSQTASFSGNLTTSTASATSTSSKRNVGDHIVPSLPLT 560 LISLLFAFI 640 ................................................................................ 80 ................................................................................ 160 ................................................................................ 240 ................................................................................ 320 ................................................................................ 400 ................................................................................ 480 ................................................................................ 560 ......... 640 Propeptide cleavage sites predicted: Arg(R)/Lys(K): 0 Name Pos Context Score Pred ____________________________v_________________ YLR120C 2 -----MK|LK 0.057 . YLR120C 4 ---MKLK|TV 0.081 . YLR120C 7 MKLKTVR|SA 0.112 . YLR120C 22 ASQVLGK|II 0.069 . YLR120C 29 IIPAANK|RD 0.058 . YLR120C 30 IPAANKR|DD 0.287 . YLR120C 37 DDDSNSK|FV 0.061 . YLR120C 40 SNSKFVK|LP 0.080 . YLR120C 45 VKLPFHK|LY 0.075 . YLR120C 58 ENVGSDK|KP 0.061 . YLR120C 59 NVGSDKK|PE 0.067 . YLR120C 63 DKKPEVR|LL 0.083 . YLR120C 66 PEVRLLK|RA 0.157 . YLR120C 67 EVRLLKR|AD 0.202 . YLR120C 126 NSMGSSR|RR 0.073 . YLR120C 127 SMGSSRR|RV 0.298 . YLR120C 128 MGSSRRR|VI 0.216 . YLR120C 132 RRRVIDK|RD 0.075 . YLR120C 133 RRVIDKR|DD 0.360 . YLR120C 201 SGSSTFR|SN 0.180 . YLR120C 272 TASHSGK|AY 0.077 . YLR120C 275 HSGKAYK|YD 0.066 . YLR120C 284 NFPIVLK|NS 0.064 . YLR120C 290 KNSGAIK|SN 0.101 . YLR120C 317 GAVDHSK|YT 0.084 . YLR120C 359 DSGSSNK|TL 0.062 . YLR120C 365 KTLTTTK|IP 0.053 . YLR120C 398 GAQYSSR|IG 0.114 . YLR120C 478 ISMAQAR|YN 0.175 . YLR120C 498 SVPSAVK|AP 0.061 . YLR120C 546 ATSTSSK|RN 0.060 . YLR120C 547 TSTSSKR|NV 0.412 . ____________________________^_________________

Fasta :-
>YLR120C ATGAAACTGAAAACTGTAAGATCTGCGGTCCTTTCGTCACTCTTTGCATCGCAGGTTCTC GGTAAGATAATACCAGCAGCAAACAAGCGCGACGACGACTCGAATTCCAAGTTCGTCAAG TTGCCCTTTCATAAGCTTTACGGGGACTCGCTAGAAAATGTGGGAAGCGACAAAAAACCG GAAGTACGCCTATTGAAGAGGGCTGACGGTTATGAAGAAATTATAATTACCAACCAGCAA AGTTTCTATTCGGTGGACTTGGAAGTGGGCACGCCACCACAGAACGTAACGGTCCTGGTG GACACAGGCTCCTCTGATCTATGGATTATGGGCTCGGATAATCCATACTGTTCTTCGAAC AGTATGGGTAGTAGCCGGAGACGTGTTATTGACAAACGTGATGATTCGTCAAGCGGCGGA TCTTTGATTAATGATATAAACCCATTTGGCTGGTTGACGGGAACGGGCAGTGCCATTGGC CCCACTGCTACGGGCTTAGGAGGCGGTTCAGGTACGGCAACTCAATCCGTGCCTGCTTCG GAAGCCACCATGGACTGTCAACAATACGGGACATTTTCCACTTCGGGCTCTTCTACATTT AGATCAAACAACACCTATTTCAGTATTAGCTACGGTGATGGGACTTTTGCCTCCGGTACT TTTGGTACGGATGTTTTGGATTTAAGCGACTTGAACGTTACCGGGTTGTCTTTTGCCGTT GCCAATGAAACGAATTCTACTATGGGTGTGTTAGGTATTGGTTTGCCCGAATTAGAAGTC ACTTATTCTGGCTCTACTGCGTCTCATAGTGGAAAAGCTTATAAATACGACAACTTCCCC ATTGTATTGAAAAATTCTGGTGCTATCAAAAGCAACACATATTCTTTGTATTTGAACGAC TCGGACGCTATGCATGGCACCATTTTGTTCGGAGCCGTGGACCACAGTAAATATACCGGC ACCTTATACACAATCCCCATCGTAAACACTCTGAGTGCTAGTGGATTTAGCTCTCCCATT CAATTTGATGTCACTATTAATGGTATCGGTATTAGTGATTCTGGGAGTAGTAACAAGACC TTGACTACCACTAAAATACCTGCTTTGTTGGATTCCGGTACTACTTTGACTTATTTACCT CAAACAGTGGTAAGTATGATCGCTACTGAACTAGGTGCGCAATACTCTTCCAGGATAGGG TATTACGTATTGGACTGTCCATCTGATGATAGTATGGAAATAGTGTTCGATTTTGGTGGT TTTCACATCAATGCACCACTTTCGAGTTTTATCTTGAGTACTGGCACTACATGTCTTTTA GGTATTATCCCAACGAGTGATGACACAGGTACCATTTTGGGTGATTCATTTTTGACTAAC GCGTACGTGGTTTATGATTTGGAGAATCTTGAAATATCCATGGCACAAGCTCGCTATAAT ACCACAAGCGAAAATATCGAAATTATTACATCCTCTGTTCCAAGCGCCGTAAAGGCACCA GGCTATACAAACACTTGGTCCACAAGTGCATCTATTGTTACCGGTGGTAACATATTTACT GTAAATTCCTCACAAACTGCTTCCTTTAGCGGTAACCTGACGACCAGTACTGCATCCGCC ACTTCTACATCAAGTAAAAGAAATGTTGGTGATCATATAGTTCCATCTTTACCCCTCACA TTAATTTCTCTTCTTTTTGCATTCATCTGA
Download Fasta

Fasta :-

MKLKTVRSAVLSSLFASQVLGKIIPAANKRDDDSNSKFVKLPFHKLYGDSLENVGSDKKP EVRLLKRADGYEEIIITNQQSFYSVDLEVGTPPQNVTVLVDTGSSDLWIMGSDNPYCSSN SMGSSRRRVIDKRDDSSSGGSLINDINPFGWLTGTGSAIGPTATGLGGGSGTATQSVPAS EATMDCQQYGTFSTSGSSTFRSNNTYFSISYGDGTFASGTFGTDVLDLSDLNVTGLSFAV ANETNSTMGVLGIGLPELEVTYSGSTASHSGKAYKYDNFPIVLKNSGAIKSNTYSLYLND SDAMHGTILFGAVDHSKYTGTLYTIPIVNTLSASGFSSPIQFDVTINGIGISDSGSSNKT LTTTKIPALLDSGTTLTYLPQTVVSMIATELGAQYSSRIGYYVLDCPSDDSMEIVFDFGG FHINAPLSSFILSTGTTCLLGIIPTSDDTGTILGDSFLTNAYVVYDLENLEISMAQARYN TTSENIEIITSSVPSAVKAPGYTNTWSTSASIVTGGNIFTVNSSQTASFSGNLTTSTASA TSTSSKRNVGDHIVPSLPLTLISLLFAFI

Pepsin-like

title: catalytic residue
coordinates: D101,D371

	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore
	YLR120C	T	172	0.517	0.026	YLR120C	T	164	0.513	0.231

	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore
	YLR120C	T	172	0.517	0.026	YLR120C	T	164	0.513	0.231

	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method
	YLR120C	270 S	TASHSGKAY	0.995	unsp	YLR120C	270 S	TASHSGKAY	0.995	unsp	YLR120C	270 S	TASHSGKAY	0.995	unsp	YLR120C	542 S	ASATSTSSK	0.991	unsp	YLR120C	544 S	ATSTSSKRN	0.995	unsp	YLR120C	136 S	KRDDSSSGG	0.996	unsp	YLR120C	210 S	YFSISYGDG	0.996	unsp

YLR120C | aspartyl protease

ID's

UniProt_ID: P32329

GEO Functions

Computed_GO_Component_IDs: GO:0031225 GO:0016020 GO:0005886

Computed_GO_Components: anchored component of membrane membrane plasma membrane

Computed_GO_Function_IDs: GO:0004190 GO:0016787 GO:0008233

Computed_GO_Functions: aspartic-type endopeptidase activity hydrolase activity peptidase activity

Computed_GO_Process_IDs: GO:0006508

Computed_GO_Processes: proteolysis

Curated_GO_Component_IDs: GO:0031362 GO:0046658 GO:0005576 GO:0009277

Curated_GO_Components: anchored component of external side of plasma membrane anchored component of plasma membrane extracellular region fungal-type cell wall

Curated_GO_Function_IDs: GO:0004190

Curated_GO_Functions: aspartic-type endopeptidase activity

Curated_GO_Processes: fungal-type cell wall organization peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion protein catabolic process protein processing proteolysis signal transduction involved in filamentous growth

Subcellular Localization

Targetp

Signalp

Fasta :-

Mitoprot

ProPeptide Prediction

Sequence

Nucleotide sequence

Fasta :-

Protein sequence

Fasta :-

Domains

Pepsin-like

Structure

Post Translational Modifications

N_Linked Glycosylation

O_Linked Glycosylation

Phosphorylation

Protein-Protein Interaction

String

YLR120C

Literature

PubMed

Google Scholar

Dinesh Gupta lab Translational bioinformatics group, ICGEB, New Delhi, India