YLR121C | aspartyl protease

UniProt_ID: Q12303

Computed_GO_Component_IDs: GO:0031225 GO:0016020 GO:0005886
Computed_GO_Components: anchored component of membrane membrane plasma membrane
Computed_GO_Function_IDs: GO:0004190 GO:0016787 GO:0008233
Computed_GO_Functions: aspartic-type endopeptidase activity hydrolase activity peptidase activity
Computed_GO_Process_IDs: GO:0006508
Computed_GO_Processes: proteolysis
Curated_GO_Component_IDs: GO:0031362 GO:0046658 GO:0005576 GO:0009277
Curated_GO_Components: anchored component of external side of plasma membrane anchored component of plasma membrane extracellular region fungal-type cell wall
Curated_GO_Function_IDs: GO:0004190
Curated_GO_Functions: aspartic-type endopeptidase activity
Curated_GO_Processes: fungal-type cell wall organization protein catabolic process proteolysis

	_ID	Prediction	OTHER	SP	mTP	CS_Position
	YLR121C	SP	0.000194	0.999490	0.000316	CS pos: 20-21. AFG-RV. Pr: 0.9494

No Results

Fasta :-
>YLR121C MKLQLAAVATLAVLTSPAFGRVLPDGKYVKIPFTKKKNGDNGELSKRSNGHEKFVLANEQ SFYSVELAIGTPSQNLTVLLDTGSADLWVPGKGNPYCGSVMDCDQYGVFDKTKSSTFKAN KSSPFYAAYGDGTYAEGAFGQDKLKYNELDLSGLSFAVANESNSTFGVLGIGLSTLEVTY SGKVAIMDKRSYEYDNFPLFLKHSGAIDATAYSLFLNDESQSSGSILFGAVDHSKYEGQL YTIPLVNLYKSQGYQHPVAFDVTLQGLGLQTDKRNITLTTTKLPALLDSGTTLTYLPSQA VALLAKSLNASYSKTLGYYEYTCPSSDNKTSVAFDFGGFRINAPLSDFTMQTSVGTCVLA IIPQAGNATAILGDSFLRNAYVVYDLDNYEISLAQAKYGTGKENVEVIKSTVPSAIRAPS YNNTWSNYASATSGGNIFTTVRTFNGTSTATTTRSTTTKKTNSTTTAKSTHKSKRALQRA ATNSASSIRSTLGLLLVPSLLILSVFFS
Download Fasta

MitoProt II - v1.101 File : /home/rajan/sadaf/4480_mitoprot/test/YLR121C.fa Sequence name : YLR121C Sequence length : 508 VALUES OF COMPUTED PARAMETERS Coef20 : 4.456 CoefTot : -1.309 ChDiff : 6 ZoneTo : 39 KR : 7 DE : 1 CleavSite : 31 HYDROPHOBIC SCALE USED GES KD GVH1 ECS H17 : 2.265 2.400 0.413 0.817 MesoH : -0.102 0.378 -0.232 0.253 MuHd_075 : 42.548 23.623 10.415 8.403 MuHd_095 : 28.687 17.871 6.653 5.744 MuHd_100 : 27.887 18.271 6.177 5.732 MuHd_105 : 28.082 17.841 6.665 6.371 Hmax_075 : 13.883 15.488 1.588 5.810 Hmax_095 : 17.500 19.900 3.299 6.170 Hmax_100 : 7.600 13.500 3.299 4.800 Hmax_105 : 19.133 20.300 3.592 7.210 CLASS NOT-MITO MITO(/CHLORO) DFM : 0.6427 0.3573 DFMC : 0.8332 0.1668

##### ProP v.1.0b ProPeptide Cleavage Site Prediction ##### ##### Furin-type cleavage site prediction (Arginine/Lysine residues) ##### 508 YLR121C MKLQLAAVATLAVLTSPAFGRVLPDGKYVKIPFTKKKNGDNGELSKRSNGHEKFVLANEQSFYSVELAIGTPSQNLTVLL 80 DTGSADLWVPGKGNPYCGSVMDCDQYGVFDKTKSSTFKANKSSPFYAAYGDGTYAEGAFGQDKLKYNELDLSGLSFAVAN 160 ESNSTFGVLGIGLSTLEVTYSGKVAIMDKRSYEYDNFPLFLKHSGAIDATAYSLFLNDESQSSGSILFGAVDHSKYEGQL 240 YTIPLVNLYKSQGYQHPVAFDVTLQGLGLQTDKRNITLTTTKLPALLDSGTTLTYLPSQAVALLAKSLNASYSKTLGYYE 320 YTCPSSDNKTSVAFDFGGFRINAPLSDFTMQTSVGTCVLAIIPQAGNATAILGDSFLRNAYVVYDLDNYEISLAQAKYGT 400 GKENVEVIKSTVPSAIRAPSYNNTWSNYASATSGGNIFTTVRTFNGTSTATTTRSTTTKKTNSTTTAKSTHKSKRALQRA 480 ATNSASSIRSTLGLLLVPSLLILSVFFS 560 ................................................................................ 80 ................................................................................ 160 ................................................................................ 240 ................................................................................ 320 ................................................................................ 400 ................................................................................ 480 ............................ 560 Propeptide cleavage sites predicted: Arg(R)/Lys(K): 0 Name Pos Context Score Pred ____________________________v_________________ YLR121C 2 -----MK|LQ 0.064 . YLR121C 21 TSPAFGR|VL 0.104 . YLR121C 27 RVLPDGK|YV 0.066 . YLR121C 30 PDGKYVK|IP 0.062 . YLR121C 35 VKIPFTK|KK 0.062 . YLR121C 36 KIPFTKK|KN 0.109 . YLR121C 37 IPFTKKK|NG 0.173 . YLR121C 46 DNGELSK|RS 0.062 . YLR121C 47 NGELSKR|SN 0.320 . YLR121C 53 RSNGHEK|FV 0.147 . YLR121C 92 DLWVPGK|GN 0.066 . YLR121C 111 QYGVFDK|TK 0.065 . YLR121C 113 GVFDKTK|SS 0.080 . YLR121C 118 TKSSTFK|AN 0.081 . YLR121C 121 STFKANK|SS 0.067 . YLR121C 143 GAFGQDK|LK 0.065 . YLR121C 145 FGQDKLK|YN 0.070 . YLR121C 183 EVTYSGK|VA 0.061 . YLR121C 189 KVAIMDK|RS 0.059 . YLR121C 190 VAIMDKR|SY 0.221 . YLR121C 202 NFPLFLK|HS 0.069 . YLR121C 235 GAVDHSK|YE 0.076 . YLR121C 250 PLVNLYK|SQ 0.087 . YLR121C 273 LGLQTDK|RN 0.058 . YLR121C 274 GLQTDKR|NI 0.143 . YLR121C 282 ITLTTTK|LP 0.052 . YLR121C 306 AVALLAK|SL 0.086 . YLR121C 314 LNASYSK|TL 0.076 . YLR121C 329 CPSSDNK|TS 0.065 . YLR121C 340 FDFGGFR|IN 0.067 . YLR121C 378 LGDSFLR|NA 0.084 . YLR121C 397 ISLAQAK|YG 0.075 . YLR121C 402 AKYGTGK|EN 0.070 . YLR121C 409 ENVEVIK|ST 0.079 . YLR121C 417 TVPSAIR|AP 0.079 . YLR121C 442 NIFTTVR|TF 0.068 . YLR121C 454 STATTTR|ST 0.164 . YLR121C 459 TRSTTTK|KT 0.086 . YLR121C 460 RSTTTKK|TN 0.104 . YLR121C 468 NSTTTAK|ST 0.105 . YLR121C 472 TAKSTHK|SK 0.094 . YLR121C 474 KSTHKSK|RA 0.069 . YLR121C 475 STHKSKR|AL 0.347 . YLR121C 479 SKRALQR|AA 0.166 . YLR121C 489 NSASSIR|ST 0.149 . ____________________________^_________________

Fasta :-
>YLR121C ATGAAACTTCAATTGGCGGCAGTGGCTACATTAGCAGTCTTAACTAGTCCGGCATTCGGT AGAGTACTTCCCGATGGGAAATACGTCAAGATTCCCTTCACAAAAAAAAAGAACGGCGAC AATGGTGAACTCAGCAAGAGATCGAACGGCCATGAAAAATTTGTACTAGCTAACGAGCAA AGCTTTTATTCTGTTGAGCTAGCCATTGGTACACCTTCACAAAACCTCACTGTGCTGTTA GACACAGGCTCAGCTGACTTATGGGTTCCTGGCAAGGGAAACCCCTACTGCGGTTCTGTG ATGGACTGTGACCAGTATGGCGTGTTCGACAAGACCAAGTCGTCCACGTTCAAAGCCAAC AAGTCCTCGCCTTTTTATGCCGCTTACGGTGACGGAACCTATGCAGAAGGTGCATTTGGT CAAGATAAATTAAAGTACAACGAATTAGACCTCAGTGGTCTATCGTTTGCCGTGGCCAAC GAATCTAACTCAACCTTTGGTGTGCTCGGGATCGGCCTTTCCACGCTTGAAGTCACCTAT TCTGGAAAAGTCGCTATTATGGACAAGAGAAGCTACGAGTATGATAACTTTCCCCTGTTC CTAAAACATTCTGGAGCCATCGATGCAACCGCATACTCTCTTTTCCTAAATGACGAGTCA CAGTCCTCCGGCAGCATCCTCTTCGGCGCTGTAGATCACAGCAAGTACGAGGGCCAACTG TACACTATCCCGTTGGTTAATCTTTATAAGTCGCAGGGTTATCAGCACCCGGTGGCGTTC GATGTCACTTTACAGGGCTTAGGACTGCAAACCGACAAGCGCAACATCACATTGACCACC ACCAAGCTCCCAGCCCTACTCGATTCAGGCACAACGCTAACATATCTGCCCTCCCAGGCA GTGGCTTTGCTAGCAAAGAGCTTGAATGCCTCGTATTCCAAGACATTGGGTTATTATGAG TACACGTGTCCCTCGAGCGACAACAAAACCAGCGTGGCCTTCGACTTCGGTGGCTTCCGT ATCAACGCTCCTCTATCCGACTTTACTATGCAGACCAGTGTGGGGACCTGTGTCTTGGCA ATAATTCCACAAGCGGGCAACGCCACCGCTATCCTTGGTGATTCCTTCTTGAGAAACGCC TACGTGGTCTACGATTTGGATAACTACGAGATTTCCCTAGCTCAAGCCAAGTATGGCACG GGGAAAGAGAACGTCGAAGTCATCAAATCTACCGTTCCCAGTGCAATAAGGGCCCCCAGT TACAACAACACTTGGTCTAACTACGCCTCCGCCACGTCCGGTGGTAATATTTTTACCACC GTGCGCACTTTCAATGGCACCAGTACTGCCACCACTACGAGGTCAACCACCACCAAGAAG ACAAACTCTACCACTACTGCAAAGTCGACTCATAAAAGCAAGAGGGCACTCCAGAGGGCT GCTACCAACTCCGCTTCCAGTATACGCTCTACCTTGGGTTTACTGCTAGTCCCCTCCTTA CTCATCCTTTCCGTTTTCTTTTCGTAA
Download Fasta

Fasta :-

MKLQLAAVATLAVLTSPAFGRVLPDGKYVKIPFTKKKNGDNGELSKRSNGHEKFVLANEQ SFYSVELAIGTPSQNLTVLLDTGSADLWVPGKGNPYCGSVMDCDQYGVFDKTKSSTFKAN KSSPFYAAYGDGTYAEGAFGQDKLKYNELDLSGLSFAVANESNSTFGVLGIGLSTLEVTY SGKVAIMDKRSYEYDNFPLFLKHSGAIDATAYSLFLNDESQSSGSILFGAVDHSKYEGQL YTIPLVNLYKSQGYQHPVAFDVTLQGLGLQTDKRNITLTTTKLPALLDSGTTLTYLPSQA VALLAKSLNASYSKTLGYYEYTCPSSDNKTSVAFDFGGFRINAPLSDFTMQTSVGTCVLA IIPQAGNATAILGDSFLRNAYVVYDLDNYEISLAQAKYGTGKENVEVIKSTVPSAIRAPS YNNTWSNYASATSGGNIFTTVRTFNGTSTATTTRSTTTKKTNSTTTAKSTHKSKRALQRA ATNSASSIRSTLGLLLVPSLLILSVFFS

Pepsin-like

title: catalytic residue
coordinates: D81,D288

	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore
	YLR121C	T	458	0.615	0.070	YLR121C	T	456	0.610	0.018	YLR121C	T	461	0.606	0.040	YLR121C	T	452	0.603	0.282	YLR121C	T	453	0.585	0.067	YLR121C	T	457	0.585	0.024	YLR121C	T	451	0.568	0.020	YLR121C	T	464	0.539	0.054	YLR121C	T	443	0.535	0.048	YLR121C	S	455	0.529	0.023	YLR121C	T	466	0.521	0.050	YLR121C	T	465	0.519	0.017

	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore
	YLR121C	T	458	0.615	0.070	YLR121C	T	456	0.610	0.018	YLR121C	T	461	0.606	0.040	YLR121C	T	452	0.603	0.282	YLR121C	T	453	0.585	0.067	YLR121C	T	457	0.585	0.024	YLR121C	T	451	0.568	0.020	YLR121C	T	464	0.539	0.054	YLR121C	T	443	0.535	0.048	YLR121C	S	455	0.529	0.023	YLR121C	T	466	0.521	0.050	YLR121C	T	465	0.519	0.017

	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method
	YLR121C	487 S	NSASSIRST	0.997	unsp	YLR121C	487 S	NSASSIRST	0.997	unsp	YLR121C	487 S	NSASSIRST	0.997	unsp	YLR121C	234 S	AVDHSKYEG	0.992	unsp	YLR121C	469 S	TTAKSTHKS	0.994	unsp

YLR121C | aspartyl protease

ID's

UniProt_ID: Q12303

GEO Functions

Computed_GO_Component_IDs: GO:0031225 GO:0016020 GO:0005886

Computed_GO_Components: anchored component of membrane membrane plasma membrane

Computed_GO_Function_IDs: GO:0004190 GO:0016787 GO:0008233

Computed_GO_Functions: aspartic-type endopeptidase activity hydrolase activity peptidase activity

Computed_GO_Process_IDs: GO:0006508

Computed_GO_Processes: proteolysis

Curated_GO_Component_IDs: GO:0031362 GO:0046658 GO:0005576 GO:0009277

Curated_GO_Components: anchored component of external side of plasma membrane anchored component of plasma membrane extracellular region fungal-type cell wall

Curated_GO_Function_IDs: GO:0004190

Curated_GO_Functions: aspartic-type endopeptidase activity

Curated_GO_Processes: fungal-type cell wall organization protein catabolic process proteolysis

Subcellular Localization

Targetp

Signalp

Fasta :-

Mitoprot

ProPeptide Prediction

Sequence

Nucleotide sequence

Fasta :-

Protein sequence

Fasta :-

Domains

Pepsin-like

Structure

Post Translational Modifications

N_Linked Glycosylation

O_Linked Glycosylation

Phosphorylation

Protein-Protein Interaction

String

YLR121C

Literature

PubMed

Google Scholar

Dinesh Gupta lab Translational bioinformatics group, ICGEB, New Delhi, India