YNL045W | bifunctional aminopeptidase/epoxide hydrolase

UniProt_ID: Q10740

Computed_GO_Component_IDs: GO:0005737 GO:0005634
Computed_GO_Components: cytoplasm nucleus
Computed_GO_Function_IDs: GO:0005488 GO:0004301 GO:0016787 GO:0004463 GO:0046872 GO:0008237 GO:0008233 GO:0008270
Computed_GO_Functions: binding epoxide hydrolase activity hydrolase activity leukotriene-A4 hydrolase activity metal ion binding metallopeptidase activity peptidase activity zinc ion binding
Computed_GO_Process_IDs: GO:0019370 GO:0006508
Computed_GO_Processes: leukotriene biosynthetic process proteolysis
Curated_GO_Component_IDs: GO:0005737 GO:0005634
Curated_GO_Components: cytoplasm nucleus
Curated_GO_Function_IDs: GO:0004177 GO:0004301 GO:0070006 GO:0042277 GO:0008270
Curated_GO_Functions: aminopeptidase activity epoxide hydrolase activity metalloaminopeptidase activity peptide binding zinc ion binding
Curated_GO_Processes: cellular lipid metabolic process peptide catabolic process protein catabolic process proteolysis

	_ID	Prediction	OTHER	SP	mTP	CS_Position
	YNL045W	mTP	0.101258	0.000102	0.898641	CS pos: 31-32. SRN-IH. Pr: 0.5161

No Results

Fasta :-
>YNL045W MFLLPFVIRHSSSIYLPTLRFRGLLTVISRNIHISTPHKMLPLSIEQRRPSRSPEYDQST LSNYKDFAVLHTDLNLSVSFEKSAISGSVTFQLKKLHEGKNKSDELHLDTSYLDVQEVHI DGSKADFQIEQRKEPLGSRLVINNASCNDNFTLNIQFRTTDKCTALQWLNSKQTKGGKPY VFSQLEAIHARSLFPCFDTPSVKSTFTASIESPLPVVFSGIRIEDTSKDTNIYRFEQKVP IPAYLIGIASGDLSSAPIGPRSTVYTEPFRLKDCQWEFENDVEKFIQTAEKIIFEYEWGT YDILVNVDSYPYGGMESPNMTFATPTLIAHDRSNIDVIAHELAHSWSGNLVTNCSWNHFW LNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQNSIDSMKDPERFSTLVQNLNDNTDP DDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPE KKEILDSVDWETWLYKPGMPPRPHFITALADNVYQLADKWVEMAQHLKTTEDFRSEFNAI DIKDFNSNQLVLFLETLTQNGHSNKKPKDFDWAKFPVASRALLDIYQDNIVKSQNAEVVF KMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNSVDRRLALATFDKFKDTYHPI CKALVKQDLGL
Download Fasta

MitoProt II - v1.101 File : /home/rajan/sadaf/4480_mitoprot/test/YNL045W.fa Sequence name : YNL045W Sequence length : 671 VALUES OF COMPUTED PARAMETERS Coef20 : 4.557 CoefTot : -0.195 ChDiff : -10 ZoneTo : 45 KR : 5 DE : 0 CleavSite : 40 HYDROPHOBIC SCALE USED GES KD GVH1 ECS H17 : 1.165 1.041 0.114 0.515 MesoH : -0.497 0.184 -0.341 0.214 MuHd_075 : 23.120 15.478 6.937 6.490 MuHd_095 : 33.104 22.524 9.088 7.903 MuHd_100 : 29.237 21.045 7.367 7.172 MuHd_105 : 25.698 21.891 7.140 6.999 Hmax_075 : 16.333 18.550 3.923 3.978 Hmax_095 : 17.300 17.900 3.413 5.970 Hmax_100 : 13.300 17.900 2.698 5.970 Hmax_105 : 11.300 15.500 1.606 5.240 CLASS NOT-MITO MITO(/CHLORO) DFM : 0.0452 0.9548 DFMC : 0.0538 0.9462 This protein is probably imported in mitochondria. f(Ser) = 0.1333 f(Arg) = 0.0889 CMi = 0.68571 CMi is the Chloroplast/Mitochondria Index It has been proposed by Von Heijne et al (Eur J Biochem,1989, 180: 535-545)

##### ProP v.1.0b ProPeptide Cleavage Site Prediction ##### ##### Furin-type cleavage site prediction (Arginine/Lysine residues) ##### 671 YNL045W MFLLPFVIRHSSSIYLPTLRFRGLLTVISRNIHISTPHKMLPLSIEQRRPSRSPEYDQSTLSNYKDFAVLHTDLNLSVSF 80 EKSAISGSVTFQLKKLHEGKNKSDELHLDTSYLDVQEVHIDGSKADFQIEQRKEPLGSRLVINNASCNDNFTLNIQFRTT 160 DKCTALQWLNSKQTKGGKPYVFSQLEAIHARSLFPCFDTPSVKSTFTASIESPLPVVFSGIRIEDTSKDTNIYRFEQKVP 240 IPAYLIGIASGDLSSAPIGPRSTVYTEPFRLKDCQWEFENDVEKFIQTAEKIIFEYEWGTYDILVNVDSYPYGGMESPNM 320 TFATPTLIAHDRSNIDVIAHELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQNSIDS 400 MKDPERFSTLVQNLNDNTDPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPE 480 KKEILDSVDWETWLYKPGMPPRPHFITALADNVYQLADKWVEMAQHLKTTEDFRSEFNAIDIKDFNSNQLVLFLETLTQN 560 GHSNKKPKDFDWAKFPVASRALLDIYQDNIVKSQNAEVVFKMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNS 640 VDRRLALATFDKFKDTYHPICKALVKQDLGL 720 ................................................................................ 80 ................................................................................ 160 ................................................................................ 240 ................................................................................ 320 ................................................................................ 400 ................................................................................ 480 ................................................................................ 560 ................................................................................ 640 ............................... 720 Propeptide cleavage sites predicted: Arg(R)/Lys(K): 0 Name Pos Context Score Pred ____________________________v_________________ YNL045W 9 LLPFVIR|HS 0.093 . YNL045W 20 IYLPTLR|FR 0.073 . YNL045W 22 LPTLRFR|GL 0.096 . YNL045W 30 LLTVISR|NI 0.099 . YNL045W 39 HISTPHK|ML 0.070 . YNL045W 48 PLSIEQR|RP 0.090 . YNL045W 49 LSIEQRR|PS 0.130 . YNL045W 52 EQRRPSR|SP 0.367 . YNL045W 65 STLSNYK|DF 0.060 . YNL045W 82 LSVSFEK|SA 0.094 . YNL045W 94 SVTFQLK|KL 0.065 . YNL045W 95 VTFQLKK|LH 0.082 . YNL045W 100 KKLHEGK|NK 0.079 . YNL045W 102 LHEGKNK|SD 0.103 . YNL045W 124 VHIDGSK|AD 0.063 . YNL045W 132 DFQIEQR|KE 0.064 . YNL045W 133 FQIEQRK|EP 0.071 . YNL045W 139 KEPLGSR|LV 0.077 . YNL045W 158 TLNIQFR|TT 0.156 . YNL045W 162 QFRTTDK|CT 0.060 . YNL045W 172 LQWLNSK|QT 0.067 . YNL045W 175 LNSKQTK|GG 0.088 . YNL045W 178 KQTKGGK|PY 0.059 . YNL045W 191 LEAIHAR|SL 0.247 . YNL045W 203 FDTPSVK|ST 0.078 . YNL045W 222 VVFSGIR|IE 0.072 . YNL045W 228 RIEDTSK|DT 0.072 . YNL045W 234 KDTNIYR|FE 0.089 . YNL045W 238 IYRFEQK|VP 0.062 . YNL045W 261 SAPIGPR|ST 0.119 . YNL045W 270 VYTEPFR|LK 0.069 . YNL045W 272 TEPFRLK|DC 0.072 . YNL045W 284 FENDVEK|FI 0.095 . YNL045W 291 FIQTAEK|II 0.077 . YNL045W 332 TLIAHDR|SN 0.229 . YNL045W 371 WTVYLER|RI 0.120 . YNL045W 372 TVYLERR|II 0.207 . YNL045W 383 IHGEPTR|HF 0.104 . YNL045W 402 NSIDSMK|DP 0.069 . YNL045W 406 SMKDPER|FS 0.097 . YNL045W 431 STVPYEK|GF 0.064 . YNL045W 446 ETILGGK|AE 0.056 . YNL045W 454 EFDPFIR|HY 0.083 . YNL045W 458 FIRHYFK|KF 0.063 . YNL045W 459 IRHYFKK|FA 0.441 . YNL045W 462 YFKKFAK|KS 0.063 . YNL045W 463 FKKFAKK|SL 0.207 . YNL045W 481 YEFYPEK|KE 0.054 . YNL045W 482 EFYPEKK|EI 0.106 . YNL045W 496 WETWLYK|PG 0.064 . YNL045W 502 KPGMPPR|PH 0.102 . YNL045W 519 VYQLADK|WV 0.080 . YNL045W 528 EMAQHLK|TT 0.072 . YNL045W 534 KTTEDFR|SE 0.110 . YNL045W 543 FNAIDIK|DF 0.066 . YNL045W 565 QNGHSNK|KP 0.063 . YNL045W 566 NGHSNKK|PK 0.082 . YNL045W 568 HSNKKPK|DF 0.135 . YNL045W 574 KDFDWAK|FP 0.070 . YNL045W 580 KFPVASR|AL 0.082 . YNL045W 592 YQDNIVK|SQ 0.067 . YNL045W 601 NAEVVFK|MF 0.068 . YNL045W 604 VVFKMFK|FQ 0.062 . YNL045W 610 KFQIFAK|LQ 0.070 . YNL045W 616 KLQEEYK|HL 0.076 . YNL045W 627 WLGTVGR|MK 0.090 . YNL045W 629 GTVGRMK|FV 0.096 . YNL045W 632 GRMKFVR|PG 0.122 . YNL045W 636 FVRPGYR|LL 0.079 . YNL045W 643 LLNSVDR|RL 0.088 . YNL045W 644 LNSVDRR|LA 0.199 . YNL045W 652 ALATFDK|FK 0.076 . YNL045W 654 ATFDKFK|DT 0.075 . YNL045W 662 TYHPICK|AL 0.070 . YNL045W 666 ICKALVK|QD 0.060 . ____________________________^_________________

Fasta :-
>YNL045W ATGTTCTTGCTTCCATTTGTCATTCGTCATTCCAGCTCTATTTACCTGCCCACGCTTCGA TTTCGAGGTTTACTTACTGTAATCTCAAGAAACATACACATTTCCACCCCTCATAAAATG TTGCCTCTTTCAATTGAGCAGAGAAGACCTTCCCGCTCCCCCGAATACGATCAGTCTACT TTATCAAATTATAAGGACTTCGCAGTTCTTCACACCGATTTAAACCTGTCTGTTTCCTTC GAAAAGTCAGCCATTTCAGGGAGCGTTACATTCCAATTGAAAAAACTGCACGAAGGTAAA AATAAATCGGATGAATTACATCTGGATACATCCTATTTGGATGTCCAGGAGGTTCATATT GATGGTTCCAAGGCAGATTTTCAAATTGAGCAAAGAAAGGAGCCATTGGGCTCCAGGTTA GTCATCAATAACGCTTCTTGCAACGATAACTTTACCTTGAATATTCAATTTCGTACGACT GACAAGTGCACCGCTTTGCAATGGTTGAACAGCAAGCAAACCAAGGGCGGTAAACCGTAC GTGTTTTCACAGTTGGAAGCTATTCATGCGAGGTCTTTGTTCCCCTGCTTTGATACTCCC TCTGTGAAGTCTACTTTCACTGCATCTATCGAGTCCCCACTACCAGTGGTTTTTTCAGGC ATCAGGATTGAAGATACAAGCAAGGATACTAATATTTACAGATTTGAACAGAAAGTCCCT ATCCCAGCCTACCTGATCGGTATTGCTTCCGGTGATTTGTCAAGCGCTCCAATTGGACCT CGTTCCACAGTTTACACTGAACCATTTCGTTTGAAAGATTGTCAATGGGAATTTGAAAAC GATGTAGAGAAATTCATTCAAACTGCAGAGAAAATTATCTTTGAATACGAGTGGGGCACT TATGATATCTTAGTTAACGTCGATTCGTACCCTTACGGCGGTATGGAGTCTCCGAATATG ACTTTTGCTACGCCCACCTTGATTGCACATGACAGATCCAACATTGATGTCATCGCCCAT GAACTTGCTCACTCATGGTCTGGTAACTTAGTGACCAATTGTTCGTGGAATCATTTTTGG TTGAATGAAGGTTGGACCGTTTACTTAGAAAGAAGAATTATTGGTGCCATTCATGGCGAA CCAACTAGACATTTCAGTGCTCTGATTGGTTGGAGCGATTTGCAGAATTCTATTGATTCT ATGAAAGATCCTGAAAGATTTTCCACTTTGGTACAAAACTTGAACGATAACACTGACCCT GACGATGCCTTTTCCACTGTTCCGTACGAAAAGGGGTTCAACTTACTATTTCACTTGGAA ACTATTTTGGGTGGTAAGGCTGAATTTGATCCATTTATTAGACACTATTTCAAGAAGTTT GCCAAAAAATCATTGGATACTTTCCAGTTTTTGGATACTTTGTATGAGTTCTATCCCGAA AAGAAAGAAATTTTGGATTCCGTTGACTGGGAAACTTGGCTGTATAAACCAGGTATGCCA CCAAGGCCTCATTTTATTACGGCTTTGGCTGATAATGTTTATCAATTGGCTGACAAGTGG GTCGAAATGGCTCAACATTTGAAAACCACAGAGGATTTCCGGTCTGAATTTAACGCTATT GACATTAAGGATTTTAATTCAAATCAATTGGTTTTGTTCTTGGAAACTTTGACACAAAAT GGCCATTCCAACAAGAAACCAAAAGATTTTGACTGGGCCAAGTTTCCCGTGGCATCTAGG GCACTGTTAGATATCTATCAAGATAACATTGTTAAATCACAGAACGCGGAAGTTGTTTTC AAGATGTTCAAATTTCAGATCTTTGCCAAGCTGCAAGAAGAATATAAGCATTTGGCCGAT TGGTTGGGAACTGTAGGTAGAATGAAGTTTGTCCGTCCCGGTTACAGACTATTAAACTCT GTAGACCGTCGATTGGCACTTGCAACTTTCGACAAATTCAAGGACACGTATCATCCAATC TGTAAAGCTCTTGTGAAACAAGATTTAGGTCTTTGA
Download Fasta

Fasta :-

MFLLPFVIRHSSSIYLPTLRFRGLLTVISRNIHISTPHKMLPLSIEQRRPSRSPEYDQST LSNYKDFAVLHTDLNLSVSFEKSAISGSVTFQLKKLHEGKNKSDELHLDTSYLDVQEVHI DGSKADFQIEQRKEPLGSRLVINNASCNDNFTLNIQFRTTDKCTALQWLNSKQTKGGKPY VFSQLEAIHARSLFPCFDTPSVKSTFTASIESPLPVVFSGIRIEDTSKDTNIYRFEQKVP IPAYLIGIASGDLSSAPIGPRSTVYTEPFRLKDCQWEFENDVEKFIQTAEKIIFEYEWGT YDILVNVDSYPYGGMESPNMTFATPTLIAHDRSNIDVIAHELAHSWSGNLVTNCSWNHFW LNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQNSIDSMKDPERFSTLVQNLNDNTDP DDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPE KKEILDSVDWETWLYKPGMPPRPHFITALADNVYQLADKWVEMAQHLKTTEDFRSEFNAI DIKDFNSNQLVLFLETLTQNGHSNKKPKDFDWAKFPVASRALLDIYQDNIVKSQNAEVVF KMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNSVDRRLALATFDKFKDTYHPI CKALVKQDLGL

Leukotriene A4 hydrolase N-terminal domain

title: Zn binding site
coordinates: H340,H344,E363

No Results

	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method
	YNL045W	226 T	RIEDTSKDT	0.995	unsp	YNL045W	226 T	RIEDTSKDT	0.995	unsp	YNL045W	226 T	RIEDTSKDT	0.995	unsp	YNL045W	400 S	NSIDSMKDP	0.998	unsp	YNL045W	563 S	QNGHSNKKP	0.994	unsp	YNL045W	51 S	QRRPSRSPE	0.997	unsp	YNL045W	53 S	RPSRSPEYD	0.995	unsp

YNL045W | bifunctional aminopeptidase/epoxide hydrolase

ID's

UniProt_ID: Q10740

GEO Functions

Computed_GO_Component_IDs: GO:0005737 GO:0005634

Computed_GO_Components: cytoplasm nucleus

Computed_GO_Function_IDs: GO:0005488 GO:0004301 GO:0016787 GO:0004463 GO:0046872 GO:0008237 GO:0008233 GO:0008270

Computed_GO_Functions: binding epoxide hydrolase activity hydrolase activity leukotriene-A4 hydrolase activity metal ion binding metallopeptidase activity peptidase activity zinc ion binding

Computed_GO_Process_IDs: GO:0019370 GO:0006508

Computed_GO_Processes: leukotriene biosynthetic process proteolysis

Curated_GO_Component_IDs: GO:0005737 GO:0005634

Curated_GO_Components: cytoplasm nucleus

Curated_GO_Function_IDs: GO:0004177 GO:0004301 GO:0070006 GO:0042277 GO:0008270

Curated_GO_Functions: aminopeptidase activity epoxide hydrolase activity metalloaminopeptidase activity peptide binding zinc ion binding

Curated_GO_Processes: cellular lipid metabolic process peptide catabolic process protein catabolic process proteolysis

Subcellular Localization

Targetp

Signalp

Fasta :-

Mitoprot

ProPeptide Prediction

Sequence

Nucleotide sequence

Fasta :-

Protein sequence

Fasta :-

Domains

Leukotriene A4 hydrolase N-terminal domain

Structure

Post Translational Modifications

N_Linked Glycosylation

O_Linked Glycosylation

Phosphorylation

Protein-Protein Interaction

String

YNL045W

Literature

PubMed

Google Scholar

Dinesh Gupta lab Translational bioinformatics group, ICGEB, New Delhi, India