YPR024W | i-AAA protease YME1

UniProt_ID: P32795

Computed_GO_Component_IDs: GO:0016020 GO:0005743 GO:0005739
Computed_GO_Components: membrane mitochondrial inner membrane mitochondrion
Computed_GO_Function_IDs: GO:0005524 GO:0016787 GO:0046872 GO:0004222 GO:0008237 GO:0000166 GO:0008233
Computed_GO_Functions: ATP binding hydrolase activity metal ion binding metalloendopeptidase activity metallopeptidase activity nucleotide binding peptidase activity
Computed_GO_Process_IDs: GO:0006508
Computed_GO_Processes: proteolysis
Curated_GO_Component_IDs: GO:0031942 GO:0005743 GO:0005739
Curated_GO_Components: i-AAA complex mitochondrial inner membrane mitochondrion
Curated_GO_Function_IDs: GO:0004176
Curated_GO_Functions: ATP-dependent peptidase activity
Curated_GO_Processes: mitochondrion organization protein folding protein import into mitochondrial intermembrane space protein import into mitochondrial matrix protein maturation protein quality control for misfolded or incompletely synthesized proteins proteolysis

	_ID	Prediction	OTHER	SP	mTP	CS_Position
	YPR024W	OTHER	0.791669	0.000294	0.208038

No Results

Fasta :-
>YPR024W MNVSKILVSPTVTTNVLRIFAPRLPQIGASLLVQKKWALRSKKFYRFYSEKNSGEMPPKK EADSSGKASNKSTISSIDNSQPPPPSNTNDKTKQANVAVSHAMLATREQEANKDLTSPDA QAAFYKLLLQSNYPQYVVSRFETPGIASSPECMELYMEALQRIGRHSEADAVRQNLLTAS SAGAVNPSLASSSSNQSGYHGNFPSMYSPLYGSRKEPLHVVVSESTFTVVSRWVKWLLVF GILTYSFSEGFKYITENTTLLKSSEVADKSVDVAKTNVKFDDVCGCDEARAELEEIVDFL KDPTKYESLGGKLPKGVLLTGPPGTGKTLLARATAGEAGVDFFFMSGSEFDEVYVGVGAK RIRDLFAQARSRAPAIIFIDELDAIGGKRNPKDQAYAKQTLNQLLVELDGFSQTSGIIII GATNFPEALDKALTRPGRFDKVVNVDLPDVRGRADILKHHMKKITLADNVDPTIIARGTP GLSGAELANLVNQAAVYACQKNAVSVDMSHFEWAKDKILMGAERKTMVLTDAARKATAFH EAGHAIMAKYTNGATPLYKATILPRGRALGITFQLPEMDKVDITKRECQARLDVCMGGKI AEELIYGKDNTTSGCGSDLQSATGTARAMVTQYGMSDDVGPVNLSENWESWSNKIRDIAD NEVIELLKDSEERARRLLTKKNVELHRLAQGLIEYETLDAHEIEQVCKGEKLDKLKTSTN TVVEGPDSDERKDIGDDKPKIPTMLNA
Download Fasta

MitoProt II - v1.101 File : /home/rajan/sadaf/4480_mitoprot/test/YPR024W.fa Sequence name : YPR024W Sequence length : 747 VALUES OF COMPUTED PARAMETERS Coef20 : 4.709 CoefTot : -0.211 ChDiff : -2 ZoneTo : 49 KR : 9 DE : 0 CleavSite : 49 HYDROPHOBIC SCALE USED GES KD GVH1 ECS H17 : 1.112 1.541 0.049 0.551 MesoH : -0.008 0.299 -0.312 0.215 MuHd_075 : 35.842 24.270 10.032 8.768 MuHd_095 : 33.206 28.308 9.187 9.106 MuHd_100 : 29.413 25.997 8.300 7.554 MuHd_105 : 31.963 20.259 7.719 7.414 Hmax_075 : 15.167 20.900 2.178 6.428 Hmax_095 : 18.900 22.600 4.175 7.508 Hmax_100 : 4.600 22.500 4.148 7.480 Hmax_105 : 7.100 19.800 2.919 5.970 CLASS NOT-MITO MITO(/CHLORO) DFM : 0.0094 0.9906 DFMC : 0.0473 0.9527 This protein is probably imported in mitochondria. f(Ser) = 0.1020 f(Arg) = 0.0816 CMi = 0.55371 CMi is the Chloroplast/Mitochondria Index It has been proposed by Von Heijne et al (Eur J Biochem,1989, 180: 535-545)

##### ProP v.1.0b ProPeptide Cleavage Site Prediction ##### ##### Furin-type cleavage site prediction (Arginine/Lysine residues) ##### 747 YPR024W MNVSKILVSPTVTTNVLRIFAPRLPQIGASLLVQKKWALRSKKFYRFYSEKNSGEMPPKKEADSSGKASNKSTISSIDNS 80 QPPPPSNTNDKTKQANVAVSHAMLATREQEANKDLTSPDAQAAFYKLLLQSNYPQYVVSRFETPGIASSPECMELYMEAL 160 QRIGRHSEADAVRQNLLTASSAGAVNPSLASSSSNQSGYHGNFPSMYSPLYGSRKEPLHVVVSESTFTVVSRWVKWLLVF 240 GILTYSFSEGFKYITENTTLLKSSEVADKSVDVAKTNVKFDDVCGCDEARAELEEIVDFLKDPTKYESLGGKLPKGVLLT 320 GPPGTGKTLLARATAGEAGVDFFFMSGSEFDEVYVGVGAKRIRDLFAQARSRAPAIIFIDELDAIGGKRNPKDQAYAKQT 400 LNQLLVELDGFSQTSGIIIIGATNFPEALDKALTRPGRFDKVVNVDLPDVRGRADILKHHMKKITLADNVDPTIIARGTP 480 GLSGAELANLVNQAAVYACQKNAVSVDMSHFEWAKDKILMGAERKTMVLTDAARKATAFHEAGHAIMAKYTNGATPLYKA 560 TILPRGRALGITFQLPEMDKVDITKRECQARLDVCMGGKIAEELIYGKDNTTSGCGSDLQSATGTARAMVTQYGMSDDVG 640 PVNLSENWESWSNKIRDIADNEVIELLKDSEERARRLLTKKNVELHRLAQGLIEYETLDAHEIEQVCKGEKLDKLKTSTN 720 TVVEGPDSDERKDIGDDKPKIPTMLNA 800 ................................................................................ 80 ................................................................................ 160 ................................................................................ 240 ................................................................................ 320 ................................................................................ 400 ................................................................................ 480 ................................................................................ 560 ................................................................................ 640 ................................................................................ 720 ........................... 800 Propeptide cleavage sites predicted: Arg(R)/Lys(K): 0 Name Pos Context Score Pred ____________________________v_________________ YPR024W 5 --MNVSK|IL 0.060 . YPR024W 18 VTTNVLR|IF 0.090 . YPR024W 23 LRIFAPR|LP 0.088 . YPR024W 35 ASLLVQK|KW 0.055 . YPR024W 36 SLLVQKK|WA 0.100 . YPR024W 40 QKKWALR|SK 0.108 . YPR024W 42 KWALRSK|KF 0.062 . YPR024W 43 WALRSKK|FY 0.244 . YPR024W 46 RSKKFYR|FY 0.175 . YPR024W 51 YRFYSEK|NS 0.075 . YPR024W 59 SGEMPPK|KE 0.061 . YPR024W 60 GEMPPKK|EA 0.172 . YPR024W 67 EADSSGK|AS 0.065 . YPR024W 71 SGKASNK|ST 0.097 . YPR024W 91 PSNTNDK|TK 0.070 . YPR024W 93 NTNDKTK|QA 0.100 . YPR024W 107 HAMLATR|EQ 0.092 . YPR024W 113 REQEANK|DL 0.069 . YPR024W 126 AQAAFYK|LL 0.068 . YPR024W 140 PQYVVSR|FE 0.136 . YPR024W 162 YMEALQR|IG 0.092 . YPR024W 165 ALQRIGR|HS 0.254 . YPR024W 173 SEADAVR|QN 0.076 . YPR024W 214 SPLYGSR|KE 0.067 . YPR024W 215 PLYGSRK|EP 0.079 . YPR024W 232 TFTVVSR|WV 0.138 . YPR024W 235 VVSRWVK|WL 0.114 . YPR024W 252 SFSEGFK|YI 0.073 . YPR024W 262 ENTTLLK|SS 0.080 . YPR024W 269 SSEVADK|SV 0.134 . YPR024W 275 KSVDVAK|TN 0.069 . YPR024W 279 VAKTNVK|FD 0.068 . YPR024W 290 CGCDEAR|AE 0.081 . YPR024W 301 EIVDFLK|DP 0.066 . YPR024W 305 FLKDPTK|YE 0.069 . YPR024W 312 YESLGGK|LP 0.067 . YPR024W 315 LGGKLPK|GV 0.082 . YPR024W 327 GPPGTGK|TL 0.059 . YPR024W 332 GKTLLAR|AT 0.090 . YPR024W 360 YVGVGAK|RI 0.071 . YPR024W 361 VGVGAKR|IR 0.102 . YPR024W 363 VGAKRIR|DL 0.158 . YPR024W 370 DLFAQAR|SR 0.118 . YPR024W 372 FAQARSR|AP 0.086 . YPR024W 388 LDAIGGK|RN 0.057 . YPR024W 389 DAIGGKR|NP 0.136 . YPR024W 392 GGKRNPK|DQ 0.153 . YPR024W 398 KDQAYAK|QT 0.073 . YPR024W 431 FPEALDK|AL 0.063 . YPR024W 435 LDKALTR|PG 0.073 . YPR024W 438 ALTRPGR|FD 0.231 . YPR024W 441 RPGRFDK|VV 0.237 . YPR024W 451 VDLPDVR|GR 0.093 . YPR024W 453 LPDVRGR|AD 0.105 . YPR024W 458 GRADILK|HH 0.074 . YPR024W 462 ILKHHMK|KI 0.072 . YPR024W 463 LKHHMKK|IT 0.113 . YPR024W 477 DPTIIAR|GT 0.090 . YPR024W 501 AVYACQK|NA 0.063 . YPR024W 515 SHFEWAK|DK 0.069 . YPR024W 517 FEWAKDK|IL 0.084 . YPR024W 524 ILMGAER|KT 0.087 . YPR024W 525 LMGAERK|TM 0.062 . YPR024W 534 VLTDAAR|KA 0.091 . YPR024W 535 LTDAARK|AT 0.081 . YPR024W 549 GHAIMAK|YT 0.088 . YPR024W 559 GATPLYK|AT 0.061 . YPR024W 565 KATILPR|GR 0.082 . YPR024W 567 TILPRGR|AL 0.099 . YPR024W 580 QLPEMDK|VD 0.058 . YPR024W 585 DKVDITK|RE 0.064 . YPR024W 586 KVDITKR|EC 0.142 . YPR024W 591 KRECQAR|LD 0.101 . YPR024W 599 DVCMGGK|IA 0.067 . YPR024W 608 EELIYGK|DN 0.070 . YPR024W 627 SATGTAR|AM 0.100 . YPR024W 654 WESWSNK|IR 0.086 . YPR024W 656 SWSNKIR|DI 0.274 . YPR024W 668 EVIELLK|DS 0.062 . YPR024W 673 LKDSEER|AR 0.069 . YPR024W 675 DSEERAR|RL 0.083 . YPR024W 676 SEERARR|LL 0.406 . YPR024W 680 ARRLLTK|KN 0.065 . YPR024W 681 RRLLTKK|NV 0.144 . YPR024W 687 KNVELHR|LA 0.095 . YPR024W 708 EIEQVCK|GE 0.057 . YPR024W 711 QVCKGEK|LD 0.054 . YPR024W 714 KGEKLDK|LK 0.057 . YPR024W 716 EKLDKLK|TS 0.061 . YPR024W 731 GPDSDER|KD 0.067 . YPR024W 732 PDSDERK|DI 0.188 . YPR024W 738 KDIGDDK|PK 0.063 . YPR024W 740 IGDDKPK|IP 0.060 . ____________________________^_________________

Fasta :-
>YPR024W ATGAACGTTTCAAAAATACTTGTGTCGCCCACGGTCACGACAAATGTTTTACGCATATTT GCTCCCAGGCTACCTCAAATCGGTGCTTCTTTGTTAGTTCAAAAAAAATGGGCCTTAAGA TCAAAGAAGTTCTACCGTTTTTATTCTGAAAAGAATAGCGGTGAAATGCCTCCTAAGAAG GAAGCTGATAGCTCTGGAAAGGCATCCAATAAATCCACGATATCTTCAATCGACAATTCG CAACCACCACCTCCATCGAACACTAATGATAAAACCAAACAAGCGAACGTAGCTGTGTCA CATGCTATGCTAGCAACTAGAGAACAAGAGGCCAATAAAGACTTAACGAGTCCTGATGCA CAAGCAGCCTTTTACAAACTTCTCTTACAATCAAACTACCCGCAATACGTGGTCTCTAGG TTTGAGACCCCCGGTATTGCGTCATCGCCTGAATGCATGGAACTGTACATGGAGGCCCTG CAGAGGATAGGCAGACACTCGGAGGCTGATGCCGTTAGACAAAACCTACTGACAGCCAGC TCTGCTGGCGCAGTTAACCCATCATTGGCGTCATCTTCATCAAACCAGTCAGGTTATCAT GGTAACTTTCCATCGATGTATTCTCCGCTTTATGGATCTCGCAAAGAGCCACTACATGTT GTCGTATCTGAATCAACTTTTACTGTTGTATCGAGATGGGTAAAGTGGCTGCTTGTTTTC GGTATCTTAACCTACTCTTTTTCTGAAGGTTTTAAATACATCACAGAAAATACAACGCTA CTAAAGTCGTCAGAAGTAGCCGACAAATCAGTTGATGTAGCTAAGACAAATGTTAAATTT GATGATGTCTGCGGTTGTGATGAGGCCCGTGCGGAATTGGAAGAAATTGTTGATTTCCTG AAAGATCCAACTAAGTACGAGTCCTTGGGTGGTAAACTACCAAAGGGTGTACTGTTGACT GGACCTCCTGGTACAGGTAAAACTTTGTTGGCTAGGGCCACTGCCGGAGAGGCTGGTGTA GATTTTTTCTTTATGTCAGGTTCTGAATTTGATGAAGTTTACGTCGGTGTTGGTGCTAAA CGTATCCGTGATTTGTTTGCTCAAGCGCGTTCTCGTGCACCAGCTATTATTTTTATTGAT GAATTAGATGCCATCGGTGGTAAGCGTAATCCAAAGGACCAAGCTTACGCCAAACAAACG TTGAATCAGTTATTGGTCGAATTAGATGGTTTCTCACAAACAAGTGGAATTATTATTATT GGTGCCACAAATTTCCCTGAGGCTTTAGATAAGGCGTTAACTAGACCAGGTAGATTTGAT AAGGTTGTGAATGTGGATTTGCCAGATGTTCGTGGTCGTGCTGATATTTTAAAGCATCAC ATGAAGAAGATTACATTGGCAGACAATGTGGATCCAACTATTATTGCGCGTGGTACCCCC GGTTTATCAGGCGCTGAGCTGGCAAATTTAGTCAACCAAGCAGCAGTTTACGCGTGTCAA AAAAATGCTGTTTCCGTTGATATGTCCCACTTCGAGTGGGCTAAGGATAAGATATTGATG GGTGCTGAGAGAAAGACTATGGTCTTAACAGATGCAGCCAGAAAGGCCACTGCTTTCCAC GAGGCTGGACATGCCATTATGGCCAAATACACCAATGGTGCTACCCCGCTATACAAGGCC ACGATATTGCCTAGAGGTAGGGCATTGGGTATTACTTTTCAATTGCCAGAAATGGATAAG GTCGACATCACCAAAAGGGAGTGTCAAGCCAGACTGGACGTGTGCATGGGGGGCAAAATT GCAGAAGAATTAATTTATGGTAAAGATAACACCACAAGTGGTTGTGGGTCTGACTTGCAA AGCGCCACCGGCACAGCAAGGGCTATGGTTACTCAATATGGTATGAGTGATGATGTAGGT CCCGTTAACTTGTCAGAAAATTGGGAATCTTGGTCTAATAAGATTCGCGATATTGCTGAT AATGAAGTGATTGAACTTTTGAAGGACTCCGAGGAAAGAGCAAGAAGACTATTAACTAAG AAAAATGTTGAGCTACATAGACTTGCGCAAGGTCTTATTGAATATGAAACTCTAGATGCC CACGAAATCGAACAAGTTTGTAAAGGTGAAAAACTGGACAAACTGAAAACTTCCACCAAT ACAGTCGTAGAAGGACCAGACAGTGATGAACGTAAAGATATAGGCGATGATAAACCCAAA ATTCCTACAATGTTAAATGCATGA
Download Fasta

Fasta :-

MNVSKILVSPTVTTNVLRIFAPRLPQIGASLLVQKKWALRSKKFYRFYSEKNSGEMPPKK EADSSGKASNKSTISSIDNSQPPPPSNTNDKTKQANVAVSHAMLATREQEANKDLTSPDA QAAFYKLLLQSNYPQYVVSRFETPGIASSPECMELYMEALQRIGRHSEADAVRQNLLTAS SAGAVNPSLASSSSNQSGYHGNFPSMYSPLYGSRKEPLHVVVSESTFTVVSRWVKWLLVF GILTYSFSEGFKYITENTTLLKSSEVADKSVDVAKTNVKFDDVCGCDEARAELEEIVDFL KDPTKYESLGGKLPKGVLLTGPPGTGKTLLARATAGEAGVDFFFMSGSEFDEVYVGVGAK RIRDLFAQARSRAPAIIFIDELDAIGGKRNPKDQAYAKQTLNQLLVELDGFSQTSGIIII GATNFPEALDKALTRPGRFDKVVNVDLPDVRGRADILKHHMKKITLADNVDPTIIARGTP GLSGAELANLVNQAAVYACQKNAVSVDMSHFEWAKDKILMGAERKTMVLTDAARKATAFH EAGHAIMAKYTNGATPLYKATILPRGRALGITFQLPEMDKVDITKRECQARLDVCMGGKI AEELIYGKDNTTSGCGSDLQSATGTARAMVTQYGMSDDVGPVNLSENWESWSNKIRDIAD NEVIELLKDSEERARRLLTKKNVELHRLAQGLIEYETLDAHEIEQVCKGEKLDKLKTSTN TVVEGPDSDERKDIGDDKPKIPTMLNA

No Results

title: ATP binding site
coordinates: P322,P323,G324,T325,G326,K327,T328,L329,D380,N424

	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore
	YPR024W	T	73	0.551	0.023	YPR024W	T	88	0.500	0.042

	ID	Site	Position	Gscore	Iscore	ID	Site	Position	Gscore	Iscore
	YPR024W	T	73	0.551	0.023	YPR024W	T	88	0.500	0.042

	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method
	YPR024W	69 S	SGKASNKST	0.992	unsp	YPR024W	69 S	SGKASNKST	0.992	unsp	YPR024W	69 S	SGKASNKST	0.992	unsp	YPR024W	167 S	IGRHSEADA	0.998	unsp	YPR024W	213 S	PLYGSRKEP	0.993	unsp	YPR024W	263 S	TLLKSSEVA	0.99	unsp	YPR024W	670 S	LLKDSEERA	0.995	unsp	YPR024W	728 S	EGPDSDERK	0.995	unsp	YPR024W	49 S	YRFYSEKNS	0.992	unsp	YPR024W	53 S	SEKNSGEMP	0.991	unsp

YPR024W | i-AAA protease YME1

ID's

UniProt_ID: P32795

GEO Functions

Computed_GO_Component_IDs: GO:0016020 GO:0005743 GO:0005739

Computed_GO_Components: membrane mitochondrial inner membrane mitochondrion

Computed_GO_Function_IDs: GO:0005524 GO:0016787 GO:0046872 GO:0004222 GO:0008237 GO:0000166 GO:0008233

Computed_GO_Functions: ATP binding hydrolase activity metal ion binding metalloendopeptidase activity metallopeptidase activity nucleotide binding peptidase activity

Computed_GO_Process_IDs: GO:0006508

Computed_GO_Processes: proteolysis

Curated_GO_Component_IDs: GO:0031942 GO:0005743 GO:0005739

Curated_GO_Components: i-AAA complex mitochondrial inner membrane mitochondrion

Curated_GO_Function_IDs: GO:0004176

Curated_GO_Functions: ATP-dependent peptidase activity

Curated_GO_Processes: mitochondrion organization protein folding protein import into mitochondrial intermembrane space protein import into mitochondrial matrix protein maturation protein quality control for misfolded or incompletely synthesized proteins proteolysis

Subcellular Localization

Targetp

Signalp

Fasta :-

Mitoprot

ProPeptide Prediction

Sequence

Nucleotide sequence

Fasta :-

Protein sequence

Fasta :-

Domains

Structure

Post Translational Modifications

N_Linked Glycosylation

O_Linked Glycosylation

Phosphorylation

Protein-Protein Interaction

String

YPR024W

Literature

PubMed

Google Scholar

Dinesh Gupta lab Translational bioinformatics group, ICGEB, New Delhi, India