• Thu. Aug 18th, 2022

Publication In Focus

  • Home
  • Lead optimization, pharmacophore development and scaffold design of protein kinase CK2 inhibitors as potential COVID-19 therapeutics

Lead optimization, pharmacophore development and scaffold design of protein kinase CK2 inhibitors as potential COVID-19 therapeutics

Abstract Therapeutic agents being designed against COVID-19 have targeted either the virus directly or the host cellular machinery. A particularly…

DriverFuse: An R package for analysis of next-generation sequencing datasets to identify cancer driver fusion genes

Abstract We developed the DriverFuse package to integrate orthogonal data types such as Structural Variants (SV) and Copy Number Variations (CNV) to…

Machine Learning Assisted Prediction of Prognostic Biomarkers Associated With COVID-19, Using Clinical and Proteomics Data

Abstract With the availability of COVID-19-related clinical data, healthcare researchers can now explore the potential of computational technologies such as…

Simultaneous Inhibition of SARS-CoV-2 Entry Pathways by Cyclosporine

Abstract The COVID-19 pandemic caused by SARS-CoV-2 represents a global public health emergency. The entry of SARS-CoV-2 into host cells…

A Plasmodium falciparum protein tyrosine phosphatase inhibitor identified from the ChEMBL-NTD database blocks parasite growth

Abstract Post-translational modifications, especially reversible phosphorylation, are among the most common mechanisms that regulate protein function and biological processes in Plasmodium species.…

Unsupervised subtyping and methylation landscape of pancreatic ductal adenocarcinoma

Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive form of pancreatic cancer that typically manifests itself at an advanced stage…

The landscape of microRNAs in plant viral infections

Abstract Viruses are importunate plant pathogens since ages. During evolution and persistent interactions with viruses, plants have developed multiple lines…

Computational Design of Novel Allosteric Inhibitors for Plasmodium falciparum DegP

Abstract The serine protease, DegP exhibits proteolytic and chaperone activities, essential for cellular protein quality control and normal cell development…

Structural insights into the mechanism of human methyltransferase hPRMT4

Abstract Human PRMT4, also known as CARM1, is a type I arginine methyltransferase protein that catalyse the formation of asymmetrical…

Plasmodium falciparum DDX17 is an RNA helicase crucial for parasite development

Abstract Malaria is one of the major global health concerns still prevailing in this 21st century. Even the effect of…