KiPhoMalaria Parasite Kinome-Phosphatome Resource

KiPho is web portal cum database for Phosphatases/Kinases predicted for Plasmodium species based on conserved domains/predicted functions present in the protein sequences.

By using search option, search can be performed for phosphatases/Kinases by typing PlasmoDB old and new ID, UniprotKB ID, Entrez Gene ID, product name or keywords. KiPho will retrieve the protein description whose description matches the entered string in the database and will be displayed on the screen. The protein of interest can be picked from the suggestions. Once protein is selected, all information can be retrieved related to the protein from our curated tables and linked publically available web sources. Information can be retrieved by clicking on various tabs as per user’s requirement and results will be displayed on screen depending on network speed. Alternatively user can go directly to phosphatase/kianse tab option, select interested species and will get information for all kinases/phosphatases of same species.

Yes! For this purpose user can simply check species for kinase/phosphatase in kinase/phosphatase option tab and all related data will be displayed. This information can be saved in html format.

You can simply search kinase/Phosphatase in search button and submit.It will list all kinases/phosphatases present in all inculded Plasmodium species in KiPho.

KiPho is web portal cum database for Phosphatases/Kinases predicted for Plasmodium species. This has been linked to PlasmoDB (a database for plasmodium species from where almost each and every information related to particular plasmodium gene can be retrieved) through PlasmoDB ID link (first column); Conserved Domain Database, NCBI for Conserved Domains present in the queried sequence (fourth column);OrthoMCL database for orthologs for the queried gene (sixth column); String database for predicted and annotated interacting partners for the queried protein based on text minig orthology, interactions computed from genomic features, co-expression, neighborhood, occurrence and experimental evidences (seventh column), PBLAST to identify template structures for 3D structure modeling (eighth column) and literature survey in PUBCHEM and google scholar to retrieve literature related to queried kinase/phosphatase.

No. Particular search data cannot be downloaded as most of the information is dynamically retireved from the parent database and once submited for that query; user leaves KiPho. Data can be downloaded from that source. However the corresponding data for all phosphatases and kinases can be downloaded in the tabular format from KiPho and also can be saved in html format for particular search.

In tab under "Download; Kinases and Phosphatases" the corresponding data for all phosphatases and kinases can be downloaded in the tabular format.

To check sequence similarity or queried plasmodium sequece identification for kinase/phosphatase can be done using local blast provided in KiPho. KiPho accepts squences in fasta format and search can be performed using both nucleotide sequences or protein sequences search. Blast will be performed using local database (538 kinases + 277 phospatases) and results will be displayed in NCBI format.

Yes. KiPho is directly linked to the source database so most of the information is dynamically retrieved and is upto date. But for remaining information it will be checked and updated in January evey year or any information which users find informative and wanted to be included in KiPho or information which is outdated will be updated if pointed to notice

Authors can be contacted using information provided in the "Contacts" option. Also, users are encouraged to contact authors for any discrepancies or point out any missing information which can be incorporated in the database.