YFL044C | ubiquitin-specific protease OTU1

UniProt_ID: P43558

Computed_GO_Component_IDs: GO:0005737 GO:0005634
Computed_GO_Components: cytoplasm nucleus
Computed_GO_Function_IDs: GO:0008234 GO:0016787 GO:0046872 GO:0003676 GO:0008233 GO:0004843 GO:0036459 GO:1904265
Computed_GO_Functions: cysteine-type peptidase activity hydrolase activity metal ion binding nucleic acid binding peptidase activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitinyl hydrolase activity ubiquitin-specific protease activity involved in negative regulation of retrograde protein
Computed_GO_Process_IDs: GO:1904153 GO:0016579 GO:0006508 GO:0030433
Computed_GO_Processes: negative regulation of retrograde protein transport, ER to cytosol protein deubiquitination proteolysis ubiquitin-dependent ERAD pathway
Curated_GO_Component_IDs: GO:0005737 GO:0005829 GO:0005634
Curated_GO_Components: cytoplasm cytosol nucleus
Curated_GO_Function_IDs: GO:0004843
Curated_GO_Functions: thiol-dependent ubiquitin-specific protease activity
Curated_GO_Processes: endoplasmic reticulum unfolded protein response protein deubiquitination regulation of transcription, DNA-templated ubiquitin-dependent ERAD pathway

	_ID	Prediction	OTHER	SP	mTP	CS_Position
	YFL044C	OTHER	0.999094	0.000639	0.000266

No Results

Fasta :-
>YFL044C MKLKVTGAGINQVVTLKQDATLNDLIEHINVDVKTMRFGYPPQRINLQGEDASLGQTQLD ELGINSGEKITIESSDSNESFSLPPPQPKPKRVLKSTEMSIGGSGENVLSVHPVLDDNSC LFHAIAYGIFKQDSVRDLREMVSKEVLNNPVKFNDAILDKPNKDYAQWILKMESWGGAIE IGIISDALAVAIYVVDIDAVKIEKFNEDKFDNYILILFNGIHYDSLTMNEFKTVFNKNQP ESDDVLTAALQLASNLKQTGYSFNTHKAQIKCNTCQMTFVGEREVARHAESTGHVDFGQN R
Download Fasta

MitoProt II - v1.101 File : /home/rajan/sadaf/4480_mitoprot/test/YFL044C.fa Sequence name : YFL044C Sequence length : 301 VALUES OF COMPUTED PARAMETERS Coef20 : 3.706 CoefTot : -0.898 ChDiff : -11 ZoneTo : 18 KR : 3 DE : 0 CleavSite : 0 HYDROPHOBIC SCALE USED GES KD GVH1 ECS H17 : 0.847 2.047 0.205 0.716 MesoH : -0.938 0.365 -0.499 0.273 MuHd_075 : 22.359 14.723 7.436 4.376 MuHd_095 : 3.301 8.336 0.964 1.526 MuHd_100 : 6.608 10.404 2.870 2.348 MuHd_105 : 12.345 13.432 5.380 3.623 Hmax_075 : 16.450 15.983 3.064 5.448 Hmax_095 : 2.625 7.175 -1.306 2.400 Hmax_100 : 8.500 11.700 0.117 3.630 Hmax_105 : 4.700 14.467 0.233 4.293 CLASS NOT-MITO MITO(/CHLORO) DFM : 0.9548 0.0452 DFMC : 0.9659 0.0341

##### ProP v.1.0b ProPeptide Cleavage Site Prediction ##### ##### Furin-type cleavage site prediction (Arginine/Lysine residues) ##### 301 YFL044C MKLKVTGAGINQVVTLKQDATLNDLIEHINVDVKTMRFGYPPQRINLQGEDASLGQTQLDELGINSGEKITIESSDSNES 80 FSLPPPQPKPKRVLKSTEMSIGGSGENVLSVHPVLDDNSCLFHAIAYGIFKQDSVRDLREMVSKEVLNNPVKFNDAILDK 160 PNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNEDKFDNYILILFNGIHYDSLTMNEFKTVFNKNQP 240 ESDDVLTAALQLASNLKQTGYSFNTHKAQIKCNTCQMTFVGEREVARHAESTGHVDFGQNR 320 ................................................................................ 80 ................................................................................ 160 ................................................................................ 240 ............................................................. 320 Propeptide cleavage sites predicted: Arg(R)/Lys(K): 0 Name Pos Context Score Pred ____________________________v_________________ YFL044C 2 -----MK|LK 0.062 . YFL044C 4 ---MKLK|VT 0.098 . YFL044C 17 NQVVTLK|QD 0.059 . YFL044C 34 HINVDVK|TM 0.062 . YFL044C 37 VDVKTMR|FG 0.092 . YFL044C 44 FGYPPQR|IN 0.102 . YFL044C 69 GINSGEK|IT 0.065 . YFL044C 89 LPPPQPK|PK 0.069 . YFL044C 91 PPQPKPK|RV 0.103 . YFL044C 92 PQPKPKR|VL 0.195 . YFL044C 95 KPKRVLK|ST 0.436 . YFL044C 131 IAYGIFK|QD 0.061 . YFL044C 136 FKQDSVR|DL 0.114 . YFL044C 139 DSVRDLR|EM 0.153 . YFL044C 144 LREMVSK|EV 0.079 . YFL044C 152 VLNNPVK|FN 0.083 . YFL044C 160 NDAILDK|PN 0.064 . YFL044C 163 ILDKPNK|DY 0.069 . YFL044C 171 YAQWILK|ME 0.070 . YFL044C 201 VDIDAVK|IE 0.055 . YFL044C 204 DAVKIEK|FN 0.072 . YFL044C 209 EKFNEDK|FD 0.067 . YFL044C 232 LTMNEFK|TV 0.075 . YFL044C 237 FKTVFNK|NQ 0.060 . YFL044C 257 QLASNLK|QT 0.083 . YFL044C 267 YSFNTHK|AQ 0.067 . YFL044C 271 THKAQIK|CN 0.071 . YFL044C 283 MTFVGER|EV 0.098 . YFL044C 287 GEREVAR|HA 0.162 . YFL044C 301 VDFGQNR|-- 0.089 . ____________________________^_________________

Fasta :-
>YFL044C ATGAAACTGAAAGTTACTGGAGCAGGAATCAACCAAGTCGTTACTTTGAAGCAAGATGCA ACACTAAATGATCTTATTGAGCATATCAATGTAGATGTTAAGACGATGAGGTTTGGATAT CCGCCTCAAAGGATCAATTTGCAAGGGGAAGACGCTTCTTTGGGACAAACCCAGCTGGAC GAGCTGGGTATTAACTCTGGTGAAAAGATTACAATAGAGTCCTCTGATAGTAACGAAAGC TTCAGTTTGCCACCACCACAACCCAAACCAAAGAGGGTGCTGAAGAGCACTGAGATGTCA ATTGGTGGCAGTGGAGAAAACGTCCTATCAGTACATCCTGTTCTCGACGACAACTCGTGT CTGTTCCATGCTATTGCCTATGGCATCTTCAAACAAGATAGCGTTCGTGACCTCAGGGAG ATGGTCTCTAAGGAGGTCCTCAACAACCCCGTCAAGTTCAATGACGCCATATTGGACAAA CCTAACAAAGATTACGCGCAATGGATTTTGAAAATGGAATCTTGGGGTGGAGCCATCGAG ATTGGTATCATATCCGATGCACTCGCAGTAGCTATTTATGTAGTCGACATTGACGCTGTT AAAATCGAAAAGTTCAACGAGGACAAGTTCGACAACTACATTTTGATACTGTTCAACGGA ATCCACTATGATTCCTTGACCATGAACGAGTTTAAAACTGTTTTCAACAAGAACCAGCCG GAATCAGATGATGTTCTAACAGCAGCTTTGCAACTGGCCTCAAATTTGAAGCAAACTGGC TATTCCTTCAACACTCATAAGGCCCAGATCAAATGCAACACTTGCCAAATGACCTTTGTG GGTGAAAGAGAAGTTGCTAGGCACGCTGAATCCACGGGACACGTTGATTTTGGCCAAAAT AGATAA
Download Fasta

Fasta :-

MKLKVTGAGINQVVTLKQDATLNDLIEHINVDVKTMRFGYPPQRINLQGEDASLGQTQLD ELGINSGEKITIESSDSNESFSLPPPQPKPKRVLKSTEMSIGGSGENVLSVHPVLDDNSC LFHAIAYGIFKQDSVRDLREMVSKEVLNNPVKFNDAILDKPNKDYAQWILKMESWGGAIE IGIISDALAVAIYVVDIDAVKIEKFNEDKFDNYILILFNGIHYDSLTMNEFKTVFNKNQP ESDDVLTAALQLASNLKQTGYSFNTHKAQIKCNTCQMTFVGEREVARHAESTGHVDFGQN R

Ubiquitin thiolesterase protein OTUB2 (Otubain-2)

title: VCP interaction site
coordinates: K4,V13,R37,Y40,P42,R44,N65,S66,G67,E68,K69,E73

	ID	Site	Position	Gscore	Iscore
	YFL044C	T	97	0.547	0.043

	ID	Site	Position	Gscore	Iscore
	YFL044C	T	97	0.547	0.043

	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method
	YFL044C	134 S	FKQDSVRDL	0.998	unsp	YFL044C	134 S	FKQDSVRDL	0.998	unsp	YFL044C	134 S	FKQDSVRDL	0.998	unsp	YFL044C	77 S	ESSDSNESF	0.992	unsp	YFL044C	96 S	RVLKSTEMS	0.991	unsp

YFL044C | ubiquitin-specific protease OTU1

ID's

UniProt_ID: P43558

GEO Functions

Computed_GO_Component_IDs: GO:0005737 GO:0005634

Computed_GO_Components: cytoplasm nucleus

Computed_GO_Function_IDs: GO:0008234 GO:0016787 GO:0046872 GO:0003676 GO:0008233 GO:0004843 GO:0036459 GO:1904265

Computed_GO_Process_IDs: GO:1904153 GO:0016579 GO:0006508 GO:0030433

Computed_GO_Processes: negative regulation of retrograde protein transport, ER to cytosol protein deubiquitination proteolysis ubiquitin-dependent ERAD pathway

Curated_GO_Component_IDs: GO:0005737 GO:0005829 GO:0005634

Curated_GO_Components: cytoplasm cytosol nucleus

Curated_GO_Function_IDs: GO:0004843

Curated_GO_Functions: thiol-dependent ubiquitin-specific protease activity

Curated_GO_Processes: endoplasmic reticulum unfolded protein response protein deubiquitination regulation of transcription, DNA-templated ubiquitin-dependent ERAD pathway

Subcellular Localization

Targetp

Signalp

Fasta :-

Mitoprot

ProPeptide Prediction

Sequence

Nucleotide sequence

Fasta :-

Protein sequence

Fasta :-

Domains

Ubiquitin thiolesterase protein OTUB2 (Otubain-2)

Structure

Post Translational Modifications

N_Linked Glycosylation

O_Linked Glycosylation

Phosphorylation

Protein-Protein Interaction

String

YFL044C

Literature

PubMed

Google Scholar

Dinesh Gupta lab Translational bioinformatics group, ICGEB, New Delhi, India