YMR223W | ubiquitin-specific protease UBP8

UniProt_ID: P50102

Computed_GO_Component_IDs: GO:0005634
Computed_GO_Components: nucleus
Computed_GO_Function_IDs: GO:0008234 GO:0016787 GO:0046872 GO:0008233 GO:0004843 GO:0036459 GO:0008270
Computed_GO_Functions: cysteine-type peptidase activity hydrolase activity metal ion binding peptidase activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitinyl hydrolase activity zinc ion binding
Computed_GO_Process_IDs: GO:0016578 GO:0016579 GO:0006508 GO:0006355 GO:0006351 GO:0006511
Computed_GO_Processes: histone deubiquitination protein deubiquitination proteolysis regulation of transcription, DNA-templated transcription, DNA-templated ubiquitin-dependent protein catabolic process
Curated_GO_Component_IDs: GO:0071819 GO:0000124 GO:0046695 GO:0005634
Curated_GO_Components: DUBm complex SAGA complex SLIK (SAGA-like) complex nucleus
Curated_GO_Function_IDs: GO:0004197 GO:0032947 GO:0004843
Curated_GO_Functions: cysteine-type endopeptidase activity protein-containing complex scaffold activity thiol-dependent ubiquitin-specific protease activity
Curated_GO_Processes: RNA splicing histone H3-K4 methylation histone H3-K79 methylation histone deubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteasomal protein catabolic process

	_ID	Prediction	OTHER	SP	mTP	CS_Position
	YMR223W	OTHER	0.999888	0.000075	0.000037

No Results

Fasta :-
>YMR223W MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCHEINSGATFMC LQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGNIDLINDAILAKYWDD VCTKTMVPSMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPD KCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHE FWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTI DPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVL QLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHK GTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQVN
Download Fasta

MitoProt II - v1.101 File : /home/rajan/sadaf/4480_mitoprot/test/YMR223W.fa Sequence name : YMR223W Sequence length : 471 VALUES OF COMPUTED PARAMETERS Coef20 : 3.189 CoefTot : -0.979 ChDiff : 2 ZoneTo : 13 KR : 0 DE : 0 CleavSite : 0 HYDROPHOBIC SCALE USED GES KD GVH1 ECS H17 : 1.641 1.306 0.385 0.518 MesoH : -0.217 0.333 -0.277 0.244 MuHd_075 : 23.487 10.275 3.396 3.545 MuHd_095 : 13.325 17.349 6.346 4.371 MuHd_100 : 3.926 16.376 3.860 3.972 MuHd_105 : 8.202 18.211 4.435 4.365 Hmax_075 : -1.800 2.800 -2.679 1.353 Hmax_095 : -5.100 5.100 -2.449 2.520 Hmax_100 : -2.900 11.500 0.151 3.750 Hmax_105 : -2.500 11.100 -0.542 3.150 CLASS NOT-MITO MITO(/CHLORO) DFM : 0.9242 0.0758 DFMC : 0.9412 0.0588

##### ProP v.1.0b ProPeptide Cleavage Site Prediction ##### ##### Furin-type cleavage site prediction (Arginine/Lysine residues) ##### 471 YMR223W MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCHEINSGATFMCLQCGFCGCWNHSHFLSHSKQ 80 IGHIFGINSNNGLLFCFKCEDYIGNIDLINDAILAKYWDDVCTKTMVPSMERRDGLSGLINMGSTCFMSSILQCLIHNPY 160 FIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHE 240 FWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKKKLYECL 320 DSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKH 400 SENGKVPDIIYELIGIVSHKGTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQVN 480 ................................................................................ 80 ................................................................................ 160 ................................................................................ 240 ................................................................................ 320 ................................................................................ 400 ....................................................................... 480 Propeptide cleavage sites predicted: Arg(R)/Lys(K): 0 Name Pos Context Score Pred ____________________________v_________________ YMR223W 15 QVFQNEK|SK 0.088 . YMR223W 17 FQNEKSK|DG 0.071 . YMR223W 22 SKDGVLK|TC 0.074 . YMR223W 28 KTCNAAR|YI 0.089 . YMR223W 37 LNHSVPK|EK 0.067 . YMR223W 39 HSVPKEK|FL 0.080 . YMR223W 45 KFLNTMK|CG 0.059 . YMR223W 79 HFLSHSK|QI 0.086 . YMR223W 98 GLLFCFK|CE 0.062 . YMR223W 116 NDAILAK|YW 0.080 . YMR223W 124 WDDVCTK|TM 0.058 . YMR223W 132 MVPSMER|RD 0.071 . YMR223W 133 VPSMERR|DG 0.251 . YMR223W 163 HNPYFIR|HS 0.107 . YMR223W 175 IHSNNCK|VR 0.067 . YMR223W 177 SNNCKVR|SP 0.268 . YMR223W 181 KVRSPDK|CF 0.074 . YMR223W 189 FSCALDK|IV 0.070 . YMR223W 201 YGALNTK|QA 0.074 . YMR223W 212 SSTSTNR|QT 0.100 . YMR223W 225 LLTCAWK|IN 0.058 . YMR223W 261 LDLPNAK|EV 0.073 . YMR223W 265 NAKEVSR|AN 0.098 . YMR223W 269 VSRANNK|QC 0.077 . YMR223W 297 GCQNNSK|TT 0.066 . YMR223W 311 DLSLDIK|DK 0.068 . YMR223W 313 SLDIKDK|KK 0.056 . YMR223W 314 LDIKDKK|KL 0.111 . YMR223W 315 DIKDKKK|LY 0.090 . YMR223W 325 CLDSFHK|KE 0.053 . YMR223W 326 LDSFHKK|EQ 0.144 . YMR223W 330 HKKEQLK|DF 0.071 . YMR223W 347 STQDAIK|QL 0.072 . YMR223W 353 KQLGIHK|LP 0.060 . YMR223W 363 VLVLQLK|RF 0.066 . YMR223W 364 LVLQLKR|FE 0.109 . YMR223W 374 LLNGSNR|KL 0.132 . YMR223W 375 LNGSNRK|LD 0.085 . YMR223W 389 PTYLNMK|NY 0.057 . YMR223W 395 KNYCSTK|EK 0.070 . YMR223W 397 YCSTKEK|DK 0.094 . YMR223W 399 STKEKDK|HS 0.070 . YMR223W 405 KHSENGK|VP 0.069 . YMR223W 420 IGIVSHK|GT 0.080 . YMR223W 433 HYIAFCK|IS 0.078 . YMR223W 441 SGGQWFK|FN 0.074 . YMR223W 457 SQEEVLK|EQ 0.058 . YMR223W 468 LLFYTIR|QV 0.129 . ____________________________^_________________

Fasta :-
>YMR223W ATGAGCATTTGTCCACATATACAGCAAGTATTTCAGAATGAAAAGTCTAAAGATGGGGTT CTAAAAACGTGCAATGCTGCCAGGTATATATTAAATCATTCCGTACCCAAGGAAAAATTC TTAAACACCATGAAATGTGGTACATGCCACGAAATAAACTCTGGTGCAACTTTCATGTGT CTACAATGTGGATTTTGTGGATGTTGGAACCATTCGCATTTTCTCTCTCACAGTAAACAG ATTGGTCACATATTTGGTATCAACTCAAATAATGGCCTTTTATTTTGCTTCAAATGTGAG GACTATATAGGGAATATCGATCTGATTAACGATGCTATCCTAGCGAAGTATTGGGACGAC GTGTGCACAAAGACCATGGTTCCTAGCATGGAAAGAAGAGATGGGCTTTCTGGCCTGATC AACATGGGATCCACTTGTTTCATGAGTAGTATTCTCCAATGTCTAATCCATAACCCTTAC TTTATTAGGCACTCAATGAGTCAAATTCATTCTAATAATTGTAAAGTGCGTTCTCCAGAT AAATGTTTTTCATGTGCACTCGATAAAATTGTTCATGAACTTTATGGAGCGCTGAATACA AAGCAAGCTTCTTCGTCATCTACATCTACTAATCGGCAAACCGGATTCATATATCTTTTA ACTTGTGCCTGGAAAATCAATCAAAATCTAGCAGGGTATTCACAACAAGATGCTCATGAA TTTTGGCAGTTTATAATTAACCAAATCCACCAAAGCTATGTTCTTGATTTGCCAAATGCC AAGGAAGTCAGCAGAGCAAATAATAAGCAGTGTGAATGCATAGTGCATACTGTGTTTGAG GGCTCCTTGGAAAGTTCTATTGTGTGTCCAGGCTGTCAAAATAATTCAAAGACAACCATT GATCCATTCTTGGATCTTTCTCTGGATATCAAGGATAAGAAAAAACTTTATGAATGTCTT GACAGTTTCCATAAAAAAGAACAGTTGAAGGATTTCAACTATCATTGTGGGGAGTGTAAC AGCACTCAAGATGCAATAAAGCAACTAGGCATACACAAATTACCATCGGTTTTGGTTTTG CAATTGAAAAGATTCGAACACCTACTTAATGGAAGTAACAGAAAACTAGACGATTTTATT GAATTTCCAACTTATTTAAATATGAAAAATTACTGTTCAACGAAGGAAAAAGATAAGCAT TCTGAAAATGGCAAGGTTCCAGACATTATTTACGAATTAATCGGTATTGTTTCCCACAAG GGGACGGTTAATGAGGGACATTATATTGCATTTTGTAAAATTTCTGGAGGGCAATGGTTT AAATTCAATGATTCCATGGTCTCCTCTATATCTCAAGAAGAGGTTTTAAAGGAACAGGCA TATTTATTATTCTACACCATTCGTCAAGTAAATTGA
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Fasta :-

MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCHEINSGATFMC LQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGNIDLINDAILAKYWDD VCTKTMVPSMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPD KCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHE FWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTI DPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVL QLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHK GTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQVN

Zf-UBP

title: Active Site
coordinates: N141,C146,H427,D444

No Results

	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method	ID	Site	Peptide	Score	Method
	YMR223W	451 S	VSSISQEEV	0.994	unsp	YMR223W	451 S	VSSISQEEV	0.994	unsp	YMR223W	451 S	VSSISQEEV	0.994	unsp	YMR223W	209 S	SSSTSTNRQ	0.991	unsp	YMR223W	393 S	KNYCSTKEK	0.993	unsp

YMR223W | ubiquitin-specific protease UBP8

ID's

UniProt_ID: P50102

GEO Functions

Computed_GO_Component_IDs: GO:0005634

Computed_GO_Components: nucleus

Computed_GO_Function_IDs: GO:0008234 GO:0016787 GO:0046872 GO:0008233 GO:0004843 GO:0036459 GO:0008270

Computed_GO_Functions: cysteine-type peptidase activity hydrolase activity metal ion binding peptidase activity thiol-dependent ubiquitin-specific protease activity thiol-dependent ubiquitinyl hydrolase activity zinc ion binding

Computed_GO_Process_IDs: GO:0016578 GO:0016579 GO:0006508 GO:0006355 GO:0006351 GO:0006511

Computed_GO_Processes: histone deubiquitination protein deubiquitination proteolysis regulation of transcription, DNA-templated transcription, DNA-templated ubiquitin-dependent protein catabolic process

Curated_GO_Component_IDs: GO:0071819 GO:0000124 GO:0046695 GO:0005634

Curated_GO_Components: DUBm complex SAGA complex SLIK (SAGA-like) complex nucleus

Curated_GO_Function_IDs: GO:0004197 GO:0032947 GO:0004843

Curated_GO_Functions: cysteine-type endopeptidase activity protein-containing complex scaffold activity thiol-dependent ubiquitin-specific protease activity

Curated_GO_Processes: RNA splicing histone H3-K4 methylation histone H3-K79 methylation histone deubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteasomal protein catabolic process

Subcellular Localization

Targetp

Signalp

Fasta :-

Mitoprot

ProPeptide Prediction

Sequence

Nucleotide sequence

Fasta :-

Protein sequence

Fasta :-

Domains

Zf-UBP

Structure

Post Translational Modifications

N_Linked Glycosylation

O_Linked Glycosylation

Phosphorylation

Protein-Protein Interaction

String

YMR223W

Literature

PubMed

Google Scholar

Dinesh Gupta lab Translational bioinformatics group, ICGEB, New Delhi, India