Plant miRNA

MicroRNAs are short ~22nt in length, yet important non-coding RNAs that regulate gene expression. Plant miRNAs have highly complementary recognition sites on their targets, which is considered to be a prominent feature of cleavage-guided repression.

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Plant miRNA Targets

This binding results in cleavage or translation inhibition of the target mRNAs. miRNAs play critical role in several essential biological processes, such as proliferation, metabolism, differentiation, development, apoptosis and cellular signaling. Hence, dysfunction of specific miRNAs is associated with variety of diseases.

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Plant miRNA and network analysis

The information about miRNA mediated network perturbations gives us better understanding on functions of miRNAs in different biological pathways.

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Welcome to PmiRNA

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Micro RNAs (miRNAs) are small RNAs of about 20 to 24 nucleotides, which regulate post-transcriptional gene expression in plants and animals. In plants, the miRNAs bind to corresponding target mRNAs to give rise to mRNA endonucleolytic cleavage, hence repressing its translation. The repression process plays an important role in governing specific roles and functions in plant development, phase change, plant architecture, and responses to biotic or abiotic stress. Several effects are brought about by perturbations in the networks of interacting proteins as a result of changes in miRNA-target interactions. The understanding of targets and linked interacting partner proteins helps in understanding downstream affects of target gene repression. PmiR-NA is a web-based tool that aids analysis of miRNA targets and its interaction network. Using this interface user can extract the information of experimentally verified miRNA genes, or look for sequence homologs in organisms. PmiR-NA also predicts target proteins for miRNA sequences along with an interface to visualize the network of proteins involving the targets. PmiR-NA integrates various types of databases like KEGG, Gene Ontology (GO), UniProt, EnsemblPlants, miRBase and GeneID to provide a better understanding and biological significance of miRNAs and role in various disease and physiological conditions.

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