Our Research Technologies:-

The scientific interests of his Group include the use of computational biology tools to solve research problems in the post-genomic era.

• Specifically, the group is interested in:-
  • Development and application of artificial intelligence-based methods to address complex biological data classification problems;
  • Computer-aided drug designing; including molecular modeling, molecular dynamics, homology modeling, virtual screening and cheminformatics for lead identification;
  • Application of comparative genomics methods to identify novel drug targets and gene expression regulatory elements like miRNAs and transcription factors;
  • Applications for Systems Biology for translational bioinformatics;
  • Computational and statistical analysis of NGS (Next Generation Sequence) data and;
  • Development of biological databases and algorithms.

Web Servers:-

1. VirulentPred
2. VsupPred – It is a SVM based webserver for predicting viral suppressor proteins.
3. Duct-BRPA-CSP – BRCA-CSP (Breast cancer stage prediction) is a web-bench developed for predicting Early and Late stage of invasive ductal carcinoma (IDC) patients using gene expression data derived from RNA-seq experiments in the form of RNA-Seq by RPKM values.
4. ASCoVPred: A web server to predict anti-SARS-CoV-2 activity and human cell toxicity of molecules
5. ProtPathDB – A database for Pathogen and Parasite Proteases
6. ApicoTFdb – Apicomplexans undergo a complex life cycle during its development across different tissues of vectors and host(s).
7. CDKIPred:- CDKIPred is a SVM based prediction method to identify novel cellular CDK inhibitor proteins using various features of proteins.
8. FaaPred:- Fungal adhesins and adhesin-like proteins prediction
9. KiPho – Protein phosphorylation/dephosphorylation is one of the key Post-Translational Modifications (PTMs) process that is regulated by the kinases and phosphatases in the competitive manner.
10. miRMOD:- miRNA modification prediction tool
11. MirtronPred:- Introns are known to be a common source of canonical microRNAs.
12. PAmiRDB is a database of computationally predicted whole genome viral targets of plant miRNA.
13. plant VsupPred:- plant VsupPred is a Random Forest based prediction tool to predict viral Suppressors of RNA silencing (VSRs).
14. PmiRNA – Micro RNAs (miRNAs) are small RNAs of about 20 to 24 nucleotides, which regulate post-transcriptional gene expression in plants and animals.
15. PRmePRed – PRmePRed is an SVM based prediction tool to predict arginine methylation sites in proteins.
16. CyclinpPred:- CyclinPred is a SVM based prediction method to identify novel cyclins using various features of proteins.
17. AHPR – Present antiviral drugs against hepatitis are ineffective to deal with recent challenges of mixed, sporadic co-infections and cancer.
18. APA:- Altered Pathway Analyzer (APA) is a cross-platform and standalone tool for analyzing gene expression datasets to highlight significantly rewired pathways across case-vs-control conditions.
19. GFF-Ex:- A genome feature extraction package
20. PSSM and SSC to SVM converter
21. 20S iPred – 20S iPred webserver assists in the classification of compounds as 20S proteasome inhibitors or non-inhibitors.
22. 20sPred – The ubiquitin/proteasome system plays a major role in overall protein turnover, in eukaryotic cells including plasmodia.
23. 3DEpiPred- Identification of conformational B-cell epitopes in antigens is an important key step in rational vaccine design.
24. DIREP:- Direct Repeats Web Server

Databases

1. M3db- Meta-Analysis of Metastatic Melonama
2. ProtvirDB:- A database of protozoan virulenProtvirDB: -t proteins