Our Research Technologies:-
The scientific interests of his Group include the use of computational biology tools to solve research problems in the post-genomic era.
- Specifically, the group is interested in:-
- Development and application of artificial intelligence-based methods to address complex biological data classification problems;
- Computer-aided drug designing; including molecular modeling, molecular dynamics, homology modeling, virtual screening and cheminformatics for lead identification;
- Application of comparative genomics methods to identify novel drug targets and gene expression regulatory elements like miRNAs and transcription factors;
- Applications for Systems Biology for translational bioinformatics;
- Computational and statistical analysis of NGS (Next Generation Sequence) data and;
- Development of biological databases and algorithms.
Web Servers:-
- VirulentPred
- VsupPred – It is a SVM based webserver for predicting viral suppressor proteins.
- Duct-BRPA-CSP – BRCA-CSP (Breast cancer stage prediction) is a web-bench developed for predicting Early and Late stage of invasive ductal carcinoma (IDC) patients using gene expression data derived from RNA-seq experiments in the form of RNA-Seq by RPKM values.
- ASCoVPred: A web server to predict anti-SARS-CoV-2 activity and human cell toxicity of molecules
- ProtPathDB – A database for Pathogen and Parasite Proteases
- ApicoTFdb – Apicomplexans undergo a complex life cycle during its development across different tissues of vectors and host(s).
- CDKIPred:- CDKIPred is a SVM based prediction method to identify novel cellular CDK inhibitor proteins using various features of proteins.
- FaaPred:- Fungal adhesins and adhesin-like proteins prediction
- KiPho – Protein phosphorylation/dephosphorylation is one of the key Post-Translational Modifications (PTMs) process that is regulated by the kinases and phosphatases in the competitive manner.
- miRMOD:- miRNA modification prediction tool
- MirtronPred:- Introns are known to be a common source of canonical microRNAs.
- PAmiRDB is a database of computationally predicted whole genome viral targets of plant miRNA.
- plant VsupPred:- plant VsupPred is a Random Forest based prediction tool to predict viral Suppressors of RNA silencing (VSRs).
- PmiRNA – Micro RNAs (miRNAs) are small RNAs of about 20 to 24 nucleotides, which regulate post-transcriptional gene expression in plants and animals.
- PRmePRed – PRmePRed is an SVM based prediction tool to predict arginine methylation sites in proteins.
- CyclinpPred:- CyclinPred is a SVM based prediction method to identify novel cyclins using various features of proteins.
- AHPR – Present antiviral drugs against hepatitis are ineffective to deal with recent challenges of mixed, sporadic co-infections and cancer.
- APA:- Altered Pathway Analyzer (APA) is a cross-platform and standalone tool for analyzing gene expression datasets to highlight significantly rewired pathways across case-vs-control conditions.
- GFF-Ex:- A genome feature extraction package
- PSSM and SSC to SVM converter
- 20S iPred – 20S iPred webserver assists in the classification of compounds as 20S proteasome inhibitors or non-inhibitors.
- 20sPred – The ubiquitin/proteasome system plays a major role in overall protein turnover, in eukaryotic cells including plasmodia.
- 3DEpiPred- Identification of conformational B-cell epitopes in antigens is an important key step in rational vaccine design.
- DIREP:- Direct Repeats Web Server